dc.contributor.author |
Zhao, Zhiyu |
|
dc.contributor.author |
Hamid, Nazimah |
|
dc.contributor.author |
Gutierrez-Maddox, Noemi |
|
dc.contributor.author |
Kam, Rothman |
|
dc.contributor.author |
Kantono, Kevin |
|
dc.contributor.author |
Wang, Kelvin |
|
dc.contributor.author |
Young, Tim |
|
dc.contributor.author |
Le, Thao T |
|
dc.contributor.author |
Lu, Jun |
|
dc.coverage.spatial |
Canada |
|
dc.date.accessioned |
2024-04-03T02:55:20Z |
|
dc.date.available |
2024-04-03T02:55:20Z |
|
dc.date.issued |
2023-10 |
|
dc.identifier.citation |
(2023). Food Research International, 172, 113131-. |
|
dc.identifier.issn |
0963-9969 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/67906 |
|
dc.description.abstract |
Studies have demonstrated avocado seeds are a good source of bioactive compounds. This study investigated the effects of roasting on the metabolites and anticancer activities of fermented avocado seeds. All three anti-cancer activities of fermented avocado seeds were higher at lower roasting temperature and time. The best inhibition effect was found against Hep G2 followed by the MDA-MB-231 and MCF-7 cancer cell lines. Untargeted metabolite profiling using gas chromatography-mass spectrometry resulted in identification of 208 metabolites. In total, 41 metabolites identified had VIP values more than 1 using PLS-R that were related to anticancer activities. All amino acids and most sugars were higher at lower roasting temperature and positively correlated to anticancer activity. The roasting conditions for optimal antioxidant and anticancer activities were determined to be 121 °C for 9 min. Findings showed that fermented avocado seed powder has the potential to become a functional food ingredient with beneficial bioctive properties. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Food research international (Ottawa, Ont.) |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Persea |
|
dc.subject |
Seeds |
|
dc.subject |
Amino Acids |
|
dc.subject |
Antineoplastic Agents |
|
dc.subject |
Antioxidants |
|
dc.subject |
Anti-cancer |
|
dc.subject |
Antioxidant |
|
dc.subject |
Avocado seeds |
|
dc.subject |
Fermentation |
|
dc.subject |
GC–MS metabolomics |
|
dc.subject |
Response surface methodology |
|
dc.subject |
Roasting |
|
dc.subject |
3205 Medical Biochemistry and Metabolomics |
|
dc.subject |
30 Agricultural, Veterinary and Food Sciences |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3006 Food Sciences |
|
dc.subject |
Cancer |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Food Science & Technology |
|
dc.subject |
GC -MS metabolomics |
|
dc.subject |
ANTICANCER ACTIVITIES |
|
dc.subject |
ANTIOXIDANT ACTIVITY |
|
dc.subject |
BIOACTIVE COMPOUNDS |
|
dc.subject |
ACID-COMPOSITION |
|
dc.subject |
HASS AVOCADO |
|
dc.subject |
TEMPERATURE |
|
dc.subject |
PROTEINS |
|
dc.subject |
AMINO |
|
dc.subject |
0904 Chemical Engineering |
|
dc.subject |
0908 Food Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.subject |
3210 Nutrition and dietetics |
|
dc.subject |
4004 Chemical engineering |
|
dc.title |
Metabolite profiling identifies chemical markers associated with the cytotoxic properties of roasted fermented avocado seeds |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.foodres.2023.113131 |
|
pubs.begin-page |
113131 |
|
pubs.volume |
172 |
|
dc.date.updated |
2024-03-14T14:42:54Z |
|
dc.rights.holder |
Copyright: Elsevier Ltd |
en |
dc.identifier.pmid |
37689896 (pubmed) |
|
pubs.author-url |
https://www.sciencedirect.com/science/article/abs/pii/S0963996923006762?via%3Dihub |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
968562 |
|
pubs.org-id |
Bioengineering Institute |
|
dc.identifier.eissn |
1873-7145 |
|
dc.identifier.pii |
S0963-9969(23)00676-2 |
|
pubs.number |
113131 |
|
pubs.record-created-at-source-date |
2024-03-15 |
|
pubs.online-publication-date |
2023-06-25 |
|