dc.contributor.author |
Cui, Haigang |
|
dc.contributor.author |
Luo, Xin |
|
dc.contributor.author |
Chen, Mingwei |
|
dc.contributor.author |
Lu, Jun |
|
dc.contributor.author |
Liu, Johnson J |
|
dc.coverage.spatial |
United Arab Emirates |
|
dc.date.accessioned |
2024-04-07T20:29:00Z |
|
dc.date.available |
2024-04-07T20:29:00Z |
|
dc.date.issued |
2023-01 |
|
dc.identifier.citation |
(2023). Current Drug Targets, 24(8), 648-661. |
|
dc.identifier.issn |
1389-4501 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/68027 |
|
dc.description.abstract |
Targeting sodium-dependent glucose transporters (SGLT1 and SGLT2) represents a new class of pharmacotherapy for type 2 diabetes mellitus, a major global health issue with an increasing social and economic burden. Following recent successes in market approvals of SGLT2 inhibitors, the ongoing effort has paved the way for the discovery of novel agents via structure-activity relationship studies, preclinical and clinical testing, including SGLT2 inhibitors, SGLT1/2 dual inhibitors, and selective SGLT1 inhibitors. A growing understanding of the physiology of SGLTs allows drug developers to explore additional cardiovascular and renal protective benefits of these agents in T2DM patients at risk. This review provides an overview of the recent investigational compounds and discusses future perspectives of drug discovery in this area. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Bentham Science Publishers |
|
dc.relation.ispartofseries |
Current drug targets |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Kidney |
|
dc.subject |
Humans |
|
dc.subject |
Diabetes Mellitus, Type 2 |
|
dc.subject |
Hypoglycemic Agents |
|
dc.subject |
Sodium-Glucose Transporter 2 |
|
dc.subject |
Sodium-Glucose Transporter 2 Inhibitors |
|
dc.subject |
HbA1c |
|
dc.subject |
SGLT1 |
|
dc.subject |
SGLT2 |
|
dc.subject |
fasting plasma glucose |
|
dc.subject |
glycemic control |
|
dc.subject |
type 2 diabetes mellitus |
|
dc.subject |
urine glucose excretion |
|
dc.subject |
3214 Pharmacology and Pharmaceutical Sciences |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
Diabetes |
|
dc.subject |
5 Development of treatments and therapeutic interventions |
|
dc.subject |
5.1 Pharmaceuticals |
|
dc.subject |
Metabolic and endocrine |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Pharmacology & Pharmacy |
|
dc.subject |
GLUCOSE COTRANSPORTER 2 |
|
dc.subject |
DUAL SGLT1/SGLT2 INHIBITOR |
|
dc.subject |
POSTPRANDIAL GLUCOSE |
|
dc.subject |
SELECTIVE INHIBITOR |
|
dc.subject |
LX4211 |
|
dc.subject |
EFFICACY |
|
dc.subject |
METFORMIN |
|
dc.subject |
HENAGLIFLOZIN |
|
dc.subject |
CANAGLIFLOZIN |
|
dc.subject |
1115 Pharmacology and Pharmaceutical Sciences |
|
dc.title |
Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of Type 2 Diabetes Mellitus |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.2174/1389450124666230503120930 |
|
pubs.issue |
8 |
|
pubs.begin-page |
648 |
|
pubs.volume |
24 |
|
dc.date.updated |
2024-03-14T14:45:24Z |
|
dc.rights.holder |
Copyright: Bentham Science Publishers |
en |
dc.identifier.pmid |
37138489 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/37138489 |
|
pubs.end-page |
661 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
961396 |
|
pubs.org-id |
Bioengineering Institute |
|
dc.identifier.eissn |
1873-5592 |
|
dc.identifier.pii |
CDT-EPUB-131434 |
|
pubs.record-created-at-source-date |
2024-03-15 |
|
pubs.online-publication-date |
2023-01-01 |
|