dc.contributor.author |
Caljé, Esther |
|
dc.contributor.author |
Oyston, Charlotte |
|
dc.contributor.author |
Wang, Zeke |
|
dc.contributor.author |
Bloomfield, Frank |
|
dc.contributor.author |
Marriott, Joy |
|
dc.contributor.author |
Dixon, Lesley |
|
dc.contributor.author |
Groom, Katie |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2024-04-07T22:57:01Z |
|
dc.date.available |
2024-04-07T22:57:01Z |
|
dc.date.issued |
2024-02 |
|
dc.identifier.citation |
(2024). Transfusion, 64(2), 301-314. |
|
dc.identifier.issn |
0041-1132 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/68050 |
|
dc.description.abstract |
<h4>Background</h4>Evidence for the management of moderate-to-severe postpartum anemia is limited. A randomized trial is needed; recruitment may be challenging.<h4>Study design and methods</h4>Randomized pilot trial with feasibility surveys.<h4>Inclusion</h4>hemoglobin 65-79 g/L, ≤7 days of birth, hemodynamically stable.<h4>Exclusion</h4>ongoing heavy bleeding; already received, or contraindication to intravenous (IV)-iron or red blood cell transfusion (RBC-T). Intervention/control: IV-iron; RBC-T; or IV-iron and RBC-T.<h4>Primary outcome</h4>number of recruits; proportion of those approached; proportion considered potentially eligible.<h4>Secondary outcomes</h4>fatigue, depression, baby-feeding, and hemoglobin at 1, 6 and 12 weeks; ferritin at 6 and 12 weeks. Surveys explored attitudes to trial participation.<h4>Results</h4>Over 16 weeks and three sites, 26/34 (76%) women approached consented to trial participation, including eight (31%) Māori women. Of those potentially eligible, 26/167 (15.6%) consented to participate. Key participation enablers were altruism and study relevance. For clinicians and stakeholders the availability of research assistance was the key barrier/enabler. Between-group rates of fatigue and depression were similar. Although underpowered to address secondary outcomes, IV-iron and RBC-T compared with RBC-T were associated with higher hemoglobin concentrations at 6 (mean difference [MD] 11.7 g/L, 95% confidence interval [CI] 2.7-20.7) and 12 (MD 12.8 g/L, 95% CI 1.5-24.2) weeks, and higher ferritin concentrations at 6 weeks (MD 136.8 mcg/L, 95% CI 76.6-196.9).<h4>Discussion</h4>Willingness to participate supports feasibility for a future trial assessing the effectiveness of IV-iron and RBC-T for postpartum anemia. Dedicated research assistance will be critical to the success of an appropriately powered trial including women-centered outcomes. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Transfusion |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Humans |
|
dc.subject |
Anemia |
|
dc.subject |
Fatigue |
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dc.subject |
Iron |
|
dc.subject |
Ferric Compounds |
|
dc.subject |
Hemoglobins |
|
dc.subject |
Hematinics |
|
dc.subject |
Erythrocyte Transfusion |
|
dc.subject |
Feasibility Studies |
|
dc.subject |
Pilot Projects |
|
dc.subject |
Postpartum Period |
|
dc.subject |
Female |
|
dc.subject |
Ferritins |
|
dc.subject |
blood transfusion |
|
dc.subject |
breastfeeding |
|
dc.subject |
intravenous infusion |
|
dc.subject |
iron deficiency |
|
dc.subject |
iron-deficiency anemia |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3201 Cardiovascular Medicine and Haematology |
|
dc.subject |
3202 Clinical Sciences |
|
dc.subject |
3204 Immunology |
|
dc.subject |
Hematology |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Clinical Research |
|
dc.subject |
6.1 Pharmaceuticals |
|
dc.subject |
6 Evaluation of treatments and therapeutic interventions |
|
dc.subject |
Blood |
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dc.subject |
Reproductive health and childbirth |
|
dc.subject |
3 Good Health and Well Being |
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dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
POSTNATAL DEPRESSION |
|
dc.subject |
DEFICIENCY ANEMIA |
|
dc.subject |
CELL TRANSFUSION |
|
dc.subject |
FACILITATORS |
|
dc.subject |
PREDICTORS |
|
dc.subject |
HEMORRHAGE |
|
dc.subject |
PREGNANCY |
|
dc.subject |
RESPONSIVENESS |
|
dc.subject |
RECRUITMENT |
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dc.subject |
SYMPTOMS |
|
dc.subject |
1102 Cardiorespiratory Medicine and Haematology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1107 Immunology |
|
dc.title |
The fatigue after infusion or transfusion pilot trial and feasibility study: A three-armed randomized pilot trial of intravenous iron and blood transfusion for the treatment of postpartum anemia |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1111/trf.17621 |
|
pubs.issue |
2 |
|
pubs.begin-page |
301 |
|
pubs.volume |
64 |
|
dc.date.updated |
2024-03-10T22:00:13Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
38149691 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/38149691 |
|
pubs.end-page |
314 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
1005770 |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Obstetrics and Gynaecology |
|
pubs.org-id |
University management |
|
pubs.org-id |
LiFePATH |
|
pubs.org-id |
Office of the Vice-Chancellor |
|
dc.identifier.eissn |
1537-2995 |
|
pubs.record-created-at-source-date |
2024-03-11 |
|
pubs.online-publication-date |
2023-12-27 |
|