dc.contributor.author |
Fang, Hua |
|
dc.contributor.author |
Zhang, Jinqiu |
|
dc.contributor.author |
Wang, Jiayuan |
|
dc.contributor.author |
Tsai, Bridget W |
|
dc.contributor.author |
Shen, Ye |
|
dc.contributor.author |
Chen, Qi |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2024-05-08T02:31:16Z |
|
dc.date.available |
2024-05-08T02:31:16Z |
|
dc.date.issued |
2024-01 |
|
dc.identifier.citation |
(2024). Placenta 145:139-142 Jan 2024 |
|
dc.identifier.issn |
0143-4004 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/68287 |
|
dc.description.abstract |
Placentae collected from elective terminations during the first trimester are commonly used as control samples in research. However, it is widely acknowledged that many complications of pregnancies can occur or originate during the early stage of gestation. This raises the question that the placentae collected from the first trimester may not accurately reflect normal placental conditions. In this study, 95 placentae were collected from elective terminations and histology was performed. Out of these, 53 placentae (56 %) exhibited the typical structure of placental villi, indicating normal development. However, 42 placentae (44 %) showed placental hydrops, with varying degrees of severity (mild, moderate, or severe). Placental hydrops has been linked to several complicated pregnancies in the later stages of gestation. Our findings suggest that the development of pregnancy pathologies could start in the first trimester, as observed by the presence of hydrops. Placental researchers should be aware of when using first-trimester placentae from termination as controls in studies. However, it remains unclear whether pathological morphologies resolve or ameliorate as the pregnancy progression or whether such placentae continue to have such pathology, but clinical symptoms/signs do not manifest. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Placenta |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Chorionic Villi |
|
dc.subject |
Placenta |
|
dc.subject |
Humans |
|
dc.subject |
Placenta Diseases |
|
dc.subject |
Edema |
|
dc.subject |
Pregnancy |
|
dc.subject |
Pregnancy Trimester, First |
|
dc.subject |
Female |
|
dc.subject |
Elective terminations |
|
dc.subject |
Morphology |
|
dc.subject |
Placental hydrops |
|
dc.subject |
3215 Reproductive Medicine |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
Contraception/Reproduction |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
3 Good Health and Well Being |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Developmental Biology |
|
dc.subject |
Obstetrics & Gynecology |
|
dc.subject |
Reproductive Biology |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.subject |
3101 Biochemistry and cell biology |
|
dc.subject |
4204 Midwifery |
|
dc.title |
The normality of the first-trimester placentae collected from elective terminations. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.placenta.2023.12.014 |
|
pubs.begin-page |
139 |
|
pubs.volume |
145 |
|
dc.date.updated |
2024-04-05T03:12:02Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
38134546 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/38134546 |
|
pubs.end-page |
142 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
1004939 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Obstetrics and Gynaecology |
|
dc.identifier.eissn |
1532-3102 |
|
dc.identifier.pii |
S0143-4004(23)00639-2 |
|
pubs.record-created-at-source-date |
2024-04-05 |
|
pubs.online-publication-date |
2023-12-15 |
|