dc.contributor.author |
Hollinshead, FK |
|
dc.contributor.author |
Hanlon, DW |
|
dc.contributor.author |
Hou, W |
|
dc.contributor.author |
Tasma, Z |
|
dc.contributor.author |
Damani, T |
|
dc.contributor.author |
Bouma, GJ |
|
dc.contributor.author |
Murtazina, DA |
|
dc.contributor.author |
Chamley, L |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2024-06-05T23:52:24Z |
|
dc.date.available |
2024-06-05T23:52:24Z |
|
dc.date.issued |
2024-05-06 |
|
dc.identifier.citation |
(2024). Journal of Equine Veterinary Science, 139:105079. |
|
dc.identifier.issn |
0737-0806 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/68605 |
|
dc.description.abstract |
Persistent breeding induced endometritis (PBIE) is a significant cause of infertility in mares. The development of a safe, universal, readily available therapeutic to manage PBIE and facilitate an optimal uterine environment for embryo development may improve pregnancy rates in susceptible mares. Mesenchymal stromal cells (MSCs) are being used increasingly as a therapeutic mediator for inflammatory conditions such as endometritis, and early gestational tissue provides a unique source of multipotent stem cells for creating MSCs. Extracellular vesicles (EVs) are mediators of cell communication produced by many different cell types. This study utilized embryo-derived mesenchymal stromal cells (EDMSCs) and their EVs as a potential therapeutic modality for PBIE in two groups: a) PBIE-susceptible mares challenged with pooled dead sperm (n=5); and b) client-owned mares diagnosed as susceptible to PBIE (n=37 mares and 40 estrous cycles). Mares pre-treated with intrauterine EDMSCs or their EVs resulted in a significant reduction in the accumulation of intrauterine fluid post-breeding. Nine of 19 (47%) mares treated with EDMSCs prior to natural breeding and 13 of 20 (65%) mares treated with EDMSC derived EVs were pregnant after the first cycle and 12 of 18 (67%) mares treated with EDMSCs, and 15 of 19 (79%) mares treated with EVs conceived by the end of the breeding season. These preliminary clinical studies are the first reports of the use of EDMSCs or their EVs as a potential intrauterine therapy for the management of PBIE susceptible mares. |
|
dc.language |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Journal of Equine Veterinary Science |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
dc.subject |
Extracellular vesicles |
|
dc.subject |
Intrauterine fluid |
|
dc.subject |
Nanosight |
|
dc.subject |
Post-breeding induced endometritis |
|
dc.subject |
Stem cells |
|
dc.subject |
3009 Veterinary Sciences |
|
dc.subject |
30 Agricultural, Veterinary and Food Sciences |
|
dc.subject |
3109 Zoology |
|
dc.subject |
31 Biological Sciences |
|
dc.subject |
Stem Cell Research |
|
dc.subject |
Pediatric |
|
dc.subject |
Reproductive health and childbirth |
|
dc.subject |
0707 Veterinary Sciences |
|
dc.title |
Use of equine embryo -derived mesenchymal stromal cells and their extracellular vesicles as a treatment for persistent breeding-induced endometritis in susceptible mares |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.jevs.2024.105079 |
|
pubs.begin-page |
105079 |
|
dc.date.updated |
2024-05-14T21:02:44Z |
|
dc.rights.holder |
Copyright: Elsevier Inc |
en |
pubs.author-url |
https://www.sciencedirect.com/science/article/abs/pii/S0737080624000856?via%3Dihub |
|
pubs.publication-status |
Published online |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
1026850 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Obstetrics and Gynaecology |
|
dc.identifier.pii |
S0737-0806(24)00085-6 |
|
pubs.number |
105079 |
|
pubs.record-created-at-source-date |
2024-05-15 |
|