dc.contributor.author |
Siu, Joey |
|
dc.contributor.author |
Johnston, James Jordan |
|
dc.contributor.author |
Pontre, Beau |
|
dc.contributor.author |
Inthavong, Kiao |
|
dc.contributor.author |
Douglas, Richard George |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2024-06-10T03:37:50Z |
|
dc.date.available |
2024-06-10T03:37:50Z |
|
dc.date.issued |
2019-09 |
|
dc.identifier.citation |
(2019). International Forum of Allergy and Rhinology, 9(9), 958-970. |
|
dc.identifier.issn |
2042-6976 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/68745 |
|
dc.description.abstract |
<h4>Background</h4>Optimizing intranasal distribution and retention of nasal sprays is essential in the management of patients with chronic rhinosinusitis (CRS), including those that have had functional endoscopic sinus surgery (FESS). Despite multiple existing distribution studies, there remains a need for a technique that allows regionalization of particle deposition within a patient's unique 3-dimensional (3D) geometry without exposing the patient to radiation.<h4>Methods</h4>Seven participants delivered normal saline containing a gadolinium-based contrast agent (GBCA) by either saline irrigation or nasal sprays on 1 side of the nasal cavity. The saline irrigation group included 2 participants (both healthy) while the nasal spray group included 5 participants (2 healthy, 2 post-FESS patients, 1 CRS patient without any sinus surgery). The distribution of new signal enhancement was assessed on each participant using magnetic resonance imaging (MRI). Serial scans were performed over an interval of 4 minutes in the nasal spray group to assess changes in intranasal distribution over time.<h4>Results</h4>Signal enhancement was widespread within the nasal cavities and maxillary sinuses of participants (both healthy) that underwent sinus irrigation. For the nasal spray participants, the hotspots for signal enhancement were similar regardless of disease status or previous history of surgery. These included the internal nasal valve, anterior septum, inferior surface of the inferior turbinate, nasal floor, and nasopharynx. No signal enhancement was detected with nasal sprays in either unoperated or operated paranasal sinuses.<h4>Conclusion</h4>A technique has been developed using MRI evaluation of radioopaque contrast to characterize the temporospatial distribution of topical drug delivery within the sinonasal cavities. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
International forum of allergy & rhinology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Nasal Cavity |
|
dc.subject |
Humans |
|
dc.subject |
Sinusitis |
|
dc.subject |
Rhinitis |
|
dc.subject |
Nasal Polyps |
|
dc.subject |
Chronic Disease |
|
dc.subject |
Gadolinium |
|
dc.subject |
Magnetic Resonance Imaging |
|
dc.subject |
Monitoring, Physiologic |
|
dc.subject |
Adult |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Nasal Lavage |
|
dc.subject |
Nasal Sprays |
|
dc.subject |
administration, intranasal |
|
dc.subject |
administration, topical |
|
dc.subject |
anti-inflammatory agents |
|
dc.subject |
drug delivery systems |
|
dc.subject |
paranasal sinuses |
|
dc.subject |
therapeutic irrigations |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3202 Clinical Sciences |
|
dc.subject |
Biomedical Imaging |
|
dc.subject |
Clinical Research |
|
dc.subject |
Neurosciences |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Otorhinolaryngology |
|
dc.subject |
administration |
|
dc.subject |
intranasal |
|
dc.subject |
topical |
|
dc.subject |
CHRONIC RHINOSINUSITIS |
|
dc.subject |
NASAL |
|
dc.subject |
DELIVERY |
|
dc.subject |
EXPOSURE |
|
dc.subject |
RISK |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
0903 Biomedical Engineering |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Diagnostic Radiology |
|
dc.subject |
1107 Immunology |
|
dc.subject |
3204 Immunology |
|
dc.title |
Magnetic resonance imaging evaluation of the distribution of spray and irrigation devices within the sinonasal cavities. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1002/alr.22376 |
|
pubs.issue |
9 |
|
pubs.begin-page |
958 |
|
pubs.volume |
9 |
|
dc.date.updated |
2024-05-02T21:25:11Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
31476267 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/31476267 |
|
pubs.end-page |
970 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RetrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
780012 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Anatomy and Medical Imaging |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
dc.identifier.eissn |
2042-6984 |
|
pubs.record-created-at-source-date |
2024-05-03 |
|
pubs.online-publication-date |
2019-09-02 |
|