dc.contributor.author |
Wagner Mackenzie, Brett |
|
dc.contributor.author |
Chang, Kevin |
|
dc.contributor.author |
Zoing, Melissa |
|
dc.contributor.author |
Jain, Ravi |
|
dc.contributor.author |
Hoggard, Michael |
|
dc.contributor.author |
Biswas, Kristi |
|
dc.contributor.author |
Douglas, Richard G |
|
dc.contributor.author |
Taylor, Michael W |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2024-06-11T23:43:47Z |
|
dc.date.available |
2024-06-11T23:43:47Z |
|
dc.date.issued |
2019-11 |
|
dc.identifier.citation |
(2019). Scientific Reports, 9(1), 17416. |
|
dc.identifier.issn |
2045-2322 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/68800 |
|
dc.description.abstract |
There is a pressing need for longitudinal studies which examine the stability of the sinonasal microbiota. In this study, we investigated bacterial and fungal community composition of the sinuses of four healthy individuals every month for one year, then once every three months for an additional year to capture seasonal variation. Sequencing of bacterial 16S rRNA genes and fungal ITS2 revealed communities that were mainly dominated by members of Actinobacteria and Basidiomycota, respectively. We observed overall shifts in both bacterial and fungal community diversity that were attributable to a combination of individual, seasonal and annual changes. The results suggest that each of the subjects possessed a strong bacterial sinonasal signature, but that fungal communities were less subject specific. Differences in fungal and bacterial diversity between subjects, and which OTUs may be correlated with seasonal differences, were investigated. A small core community that persisted throughout the two year sampling period was identified: Corynebacterium, Propionibacterium and Staphylococcus, and one type of fungus, Malassezia restricta. It is likely that bacterial and fungal airway microbiomes are dynamic and experience natural shifts in diversity with time. The underlying reasons for these shifts appear to be a combination of changes in environmental climate and host factors. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Scientific reports |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Paranasal Sinuses |
|
dc.subject |
Humans |
|
dc.subject |
Bacteria |
|
dc.subject |
Fungi |
|
dc.subject |
DNA, Ribosomal Spacer |
|
dc.subject |
RNA, Ribosomal, 16S |
|
dc.subject |
Regression Analysis |
|
dc.subject |
Computational Biology |
|
dc.subject |
Biodiversity |
|
dc.subject |
Seasons |
|
dc.subject |
Metagenomics |
|
dc.subject |
Microbiota |
|
dc.subject |
3107 Microbiology |
|
dc.subject |
31 Biological Sciences |
|
dc.subject |
3103 Ecology |
|
dc.subject |
Infectious Diseases |
|
dc.subject |
Clinical Research |
|
dc.subject |
Infection |
|
dc.subject |
Science & Technology |
|
dc.subject |
Multidisciplinary Sciences |
|
dc.subject |
Science & Technology - Other Topics |
|
dc.subject |
CHRONIC RHINOSINUSITIS RICHNESS |
|
dc.subject |
POSTOPERATIVE CHANGES |
|
dc.subject |
COMMUNITIES |
|
dc.subject |
CLADOSPORIUM |
|
dc.subject |
DYNAMICS |
|
dc.subject |
ECOLOGY |
|
dc.subject |
AIR |
|
dc.subject |
0605 Microbiology |
|
dc.subject |
Clinical Medicine and Science |
|
dc.title |
Longitudinal study of the bacterial and fungal microbiota in the human sinuses reveals seasonal and annual changes in diversity |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41598-019-53975-9 |
|
pubs.issue |
1 |
|
pubs.begin-page |
17416 |
|
pubs.volume |
9 |
|
dc.date.updated |
2024-05-02T21:22:49Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
31758066 (pubmed) |
|
pubs.author-url |
https://www.nature.com/articles/s41598-019-53975-9 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
788327 |
|
pubs.org-id |
Arts |
|
pubs.org-id |
Engineering |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Science |
|
pubs.org-id |
Arts Research |
|
pubs.org-id |
Compass |
|
pubs.org-id |
Biological Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
pubs.org-id |
Chemical and Materials Eng |
|
dc.identifier.eissn |
2045-2322 |
|
dc.identifier.pii |
10.1038/s41598-019-53975-9 |
|
pubs.number |
17416 |
|
pubs.record-created-at-source-date |
2024-05-03 |
|
pubs.online-publication-date |
2019-11-22 |
|