dc.contributor.author |
Rokohl, Alexander C |
|
dc.contributor.author |
Trester, Marc |
|
dc.contributor.author |
Naderi, Parsa |
|
dc.contributor.author |
Loreck, Niklas |
|
dc.contributor.author |
Zwingelberg, Sarah |
|
dc.contributor.author |
Bucher, Franziska |
|
dc.contributor.author |
Pine, Keith R |
|
dc.contributor.author |
Heindl, Ludwig M |
|
dc.date.accessioned |
2024-07-11T03:28:32Z |
|
dc.date.available |
2024-07-11T03:28:32Z |
|
dc.date.issued |
2021-12 |
|
dc.identifier.citation |
(2021). Eye, 35(12), 3358-3366. |
|
dc.identifier.issn |
0950-222X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/69147 |
|
dc.description.abstract |
Purpose:
To evaluate morphological alterations of meibomian glands (MGs) in the dry anophthalmic socket syndrome (DASS).
Methods:
Fifteen unilateral anophthalmic patients wearing cryolite glass prosthetic eyes were enrolled. All patients with clinical blepharitis or other significant eyelid abnormalities were excluded. In vivo laser scanning confocal microscopy (LSCM) of the MGs in the lower eyelids both on the anophthalmic side and the healthy fellow eye was performed to quantify acinar unit density, acinar unit diameter, acinar unit area, meibum secretion reflectivity, the inhomogeneous appearance of the glandular interstice, and inhomogeneous appearance of the acinar walls.
Results:
The lower eyelids of the anophthalmic sockets revealed a significant reduction of the acinar unit density (p = 0.003) as well as a significantly more inhomogeneous appearance of the periglandular interstices (p = 0.018) and the acinar unit walls (p = 0.015) than the healthy fellow eyelid. However, there were no significant differences regarding the acinar unit diameter, acinar unit area, and meibum secretion reflectivity of the MGs on the anophthalmic side compared to the healthy fellow eyelid (p ≥ 0.05, respectively).
Conclusions:
The eyelids of anophthalmic sockets without clinical blepharitis demonstrate a reduced density of MG acinar units and a more inhomogeneous appearance of the periglandular interstices and the acinar unit walls. This can cause meibomian gland dysfunction contributing to DASS and suggests early treatment of these symptomatic patients, even in the clinical absence of any blepharitis signs. |
|
dc.language |
en |
|
dc.publisher |
Springer Nature |
|
dc.relation.ispartofseries |
Eye |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
32 Biomedical and Clinical Sciences |
|
dc.subject |
3212 Ophthalmology and Optometry |
|
dc.subject |
Eye Disease and Disorders of Vision |
|
dc.subject |
Anophthalmos |
|
dc.subject |
Blepharitis |
|
dc.subject |
Eyelid Diseases |
|
dc.subject |
Humans |
|
dc.subject |
Meibomian Glands |
|
dc.subject |
Microscopy, Confocal |
|
dc.subject |
Syndrome |
|
dc.subject |
Tears |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1107 Immunology |
|
dc.subject |
1113 Opthalmology and Optometry |
|
dc.subject |
3204 Immunology |
|
dc.title |
Dry anophthalmic socket syndrome – morphological alterations in meibomian glands |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41433-021-01426-z |
|
pubs.issue |
12 |
|
pubs.begin-page |
3358 |
|
pubs.volume |
35 |
|
dc.date.updated |
2024-06-03T06:04:44Z |
|
dc.rights.holder |
Copyright: The authors |
en |
dc.identifier.pmid |
33564141 (pubmed) |
|
pubs.end-page |
3366 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.elements-id |
1029953 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Optometry and Vision Science |
|
dc.identifier.eissn |
1476-5454 |
|
pubs.record-created-at-source-date |
2024-06-03 |
|
pubs.online-publication-date |
2021-02-09 |
|