dc.contributor.author |
Das, Subhasish |
|
dc.contributor.author |
McClintock, Thomas |
|
dc.contributor.author |
Cormack, Barbara E |
|
dc.contributor.author |
Bloomfield, Frank H |
|
dc.contributor.author |
Harding, Jane E |
|
dc.contributor.author |
Lin, Luling |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2024-07-11T23:03:38Z |
|
dc.date.available |
2024-07-11T23:03:38Z |
|
dc.date.issued |
2024-06-10 |
|
dc.identifier.citation |
(2024). Pediatric Research. |
|
dc.identifier.issn |
0031-3998 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/69180 |
|
dc.description.abstract |
BACKGROUND: Appropriate protein intake is crucial for growth and development in children born preterm. We assessed the effects of high (HP) versus low protein (LP) intake on neurodevelopment, growth, and biochemical anomalies in these children. METHODS: Randomised and quasi-randomised trials providing protein to children born preterm (<37 completed weeks of gestation) were searched following PRISMA guideline in three databases and four registers (PROSPERO registration CRD42022325659). Random-effects model was used for assessing the effects of HP (≥3.5 g/kg/d) vs. LP (<3.5 g/kg/d). RESULTS: Data from forty-four studies (n = 5338) showed HP might slightly reduce the chance of survival without neurodisability at ≥12 months (four studies, 1109 children, relative risk [RR] 0.95 [95% CI 0.90, 1.01]; P = 0.13; low certainty evidence) and might increase risk of cognitive impairment at toddler age (two studies; 436 children; RR 1.36 [0.89, 2.09]; P = 0.16; low certainty evidence). At discharge or 36 weeks, HP intake might result in higher weight and greater head circumference z-scores. HP intake probably increased the risk of hypophosphatemia, hypercalcemia, refeeding syndrome and high blood urea, but reduced risk of hyperglycaemia. CONCLUSIONS: HP intake for children born preterm may be harmful for neonatal metabolism and later neurodisability and has few short-term benefits for growth. IMPACT STATEMENT: Planned high protein intake after birth for infants born preterm might be harmful for survival, neurodisability and metabolism during infancy and did not improve growth after the neonatal period. Protein intake ≥3.5 g/kg/d should not be recommended for children born preterm. |
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dc.language |
eng |
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dc.publisher |
Springer Science and Business Media LLC |
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dc.relation.ispartofseries |
Pediatr Res |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
3213 Paediatrics |
|
dc.title |
High protein intake on later outcomes in preterm children: a systematic review and meta-analysis. |
|
dc.type |
Journal Article |
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dc.identifier.doi |
10.1038/s41390-024-03296-z |
|
dc.date.updated |
2024-06-12T13:19:04Z |
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dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/38858504 |
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pubs.publication-status |
Published online |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.subtype |
Systematic Review |
|
pubs.elements-id |
1031055 |
|
pubs.org-id |
Liggins Institute |
|
pubs.org-id |
University management |
|
pubs.org-id |
LiFePATH |
|
pubs.org-id |
Office of the Vice-Chancellor |
|
dc.identifier.eissn |
1530-0447 |
|
dc.identifier.pii |
10.1038/s41390-024-03296-z |
|
pubs.record-created-at-source-date |
2024-06-13 |
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pubs.online-publication-date |
2024-06-10 |
|