dc.contributor.author |
Han, Yue |
|
dc.contributor.author |
Spicer, Julie |
|
dc.contributor.author |
Huang, Yuan |
|
dc.contributor.author |
Bunt, Craig |
|
dc.contributor.author |
Liu, Mengyang |
|
dc.contributor.author |
Wen, Jingyuan |
|
dc.date.accessioned |
2024-07-12T02:35:35Z |
|
dc.date.available |
2024-07-12T02:35:35Z |
|
dc.date.issued |
2024-01-01 |
|
dc.identifier.citation |
(2024). European Journal of Lipid Science and Technology. |
|
dc.identifier.issn |
0931-5985 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/69214 |
|
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>With the growing prevalence of diabetes, there is an urgent demand for a user‐friendly treatment option that minimizes side effects related to the use of subcutaneous injections. Scientists have dedicated over a century to developing an oral dosage form of insulin that can be administrated orally. The oral route of administration is the most desirable route for regularly dosed drugs in terms of safety and patient compliance. However, oral delivery of insulin remains a formidable challenge due to its intrinsically limited ability to cross the intestinal epithelium membrane and susceptibility to enzymatic degradation. This article reviews oral insulin research over the past decade, with a particular focus on surface modifications of nanoparticles (NPs). Various strategies involving controlling surface charges, utilizing protective proteins, and targeting specific receptors with ligands have been explored. Notably, surface modifications of the NPs for targeting specific intestinal receptors have shown promise in enhancing insulin oral absorption and bioavailability. Advanced technologies such as oral microneedles and gene therapy have also been developed, but their safety requires further assessment. Despite encouraging preclinical results across numerous strategies, the current clinical evidence is less optimistic. In summary, the present findings highlight the substantial journey that still lies ahead before achieving successful oral delivery of insulin.</jats:p><jats:p><jats:italic>Practical Applications</jats:italic>: This review provides a summary of recent progress in oral insulin delivery, particularly highlighting surface‐modified functional nanoparticles serving as an effective drug delivery system, which offers valuable information to the researchers. Due to the limited effectiveness of oral protein drugs caused by biological barriers, innovative technologies and drug delivery systems have been developed to overcome these obstacles and achieve therapeutic goals. This review concluded that surface modifications to nanoparticles can improve insulin stability and permeability, thereby enhancing oral bioavailability. It could assist researchers in developing more effective and patient‐friendly oral drug delivery systems.</jats:p> |
|
dc.language |
en |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
European Journal of Lipid Science and Technology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/4.0/ |
|
dc.subject |
34 Chemical Sciences |
|
dc.subject |
Bioengineering |
|
dc.subject |
Diabetes |
|
dc.subject |
Minority Health |
|
dc.subject |
Nanotechnology |
|
dc.subject |
Digestive Diseases |
|
dc.subject |
Biotechnology |
|
dc.subject |
Health Disparities |
|
dc.subject |
5.1 Pharmaceuticals |
|
dc.subject |
5.2 Cellular and gene therapies |
|
dc.subject |
5 Development of treatments and therapeutic interventions |
|
dc.subject |
03 Chemical Sciences |
|
dc.subject |
10 Technology |
|
dc.title |
Advancements in oral insulin: A century of research and the emergence of targeted nanoparticle strategies |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1002/ejlt.202300271 |
|
dc.date.updated |
2024-06-25T18:25:26Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published online |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Review |
|
pubs.elements-id |
1034213 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Auckland Cancer Research |
|
dc.identifier.eissn |
1438-9312 |
|
pubs.record-created-at-source-date |
2024-06-26 |
|
pubs.online-publication-date |
2024-06-16 |
|