dc.contributor.author |
Nevalainen, KMH |
en |
dc.contributor.author |
Te'o, VSJ |
en |
dc.contributor.author |
Bergquist, Peter |
en |
dc.date.accessioned |
2011-07-24T21:45:02Z |
en |
dc.date.issued |
2005-09-01 |
en |
dc.identifier.citation |
Trends Biotechnol 23(9):468-474 Sep 2005 |
en |
dc.identifier.issn |
0167-7799 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/7055 |
en |
dc.description.abstract |
Filamentous fungi are commonly used in the fermentation industry for the large-scale production of proteins mainly industrial enzymes. Recent advances in fungal genomics and related experimental technologies such as gene arrays and proteornics are rapidly changing the approaches to the development and use of filamentous fungi as hosts for the production of both homologous and heterologous gene products. The emphasis is moving towards sourcing new genes of interest through database mining and unravelling the circuits related to fungal gene regulation, applying, for example, transcriptomics. However, although heterologous fungal proteins are efficiently expressed, expression of gene products from other organisms is subject to several bottlenecks that reduce yield. Current approaches emphasize the study of pathways involved in protein modification and degradation in general rather than gene-by-gene approaches. |
en |
dc.language |
English |
en |
dc.publisher |
ELSEVIER SCIENCE LONDON |
en |
dc.relation.ispartofseries |
TRENDS IN BIOTECHNOLOGY |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0167-7799/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Biotechnology & Applied Microbiology |
en |
dc.subject |
YEAST PICHIA-PASTORIS |
en |
dc.subject |
NIGER VAR. AWAMORI |
en |
dc.subject |
TRICHODERMA-REESEI |
en |
dc.subject |
ASPERGILLUS-NIGER |
en |
dc.subject |
ENDOPLASMIC-RETICULUM |
en |
dc.subject |
SECRETORY PATHWAY |
en |
dc.subject |
DOWN-REGULATION |
en |
dc.subject |
QUALITY-CONTROL |
en |
dc.subject |
GENE |
en |
dc.subject |
GLYCOSYLATION |
en |
dc.title |
Heterologous protein expression in filamentous fungi |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.tibtech.2005.06.002 |
en |
pubs.issue |
9 |
en |
pubs.begin-page |
468 |
en |
pubs.volume |
23 |
en |
dc.rights.holder |
Copyright: 2005 Elsevier Ltd. |
en |
dc.identifier.pmid |
15967521 |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000232128500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.end-page |
474 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
197356 |
en |
pubs.record-created-at-source-date |
2013-06-05 |
en |
pubs.dimensions-id |
15967521 |
en |