Localization of AMPA-selective glutamate receptors in the auditory brainstem of the barn owl

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dc.contributor.author Levin, MD en
dc.contributor.author Kubke, Maria en
dc.contributor.author Schneider, M en
dc.contributor.author Wenthold, R en
dc.contributor.author Carr, CE en
dc.date.accessioned 2011-08-11T04:03:17Z en
dc.date.issued 1997 en
dc.identifier.citation Journal of Comparative Neurology 378:239-253 1997 en
dc.identifier.issn 0021-9967 en
dc.identifier.uri http://hdl.handle.net/2292/7304 en
dc.description.abstract AMPA receptor subunit-specific antibodies were used to determine if the distribution of excitatory amino acid receptors in the owl's auditory brainstem and midbrain nuclei reflected specializations for temporal processing. Each auditory nucleus displays characteristic levels of immunostaining for the AMPA receptor subunits GluR1–4, with high levels of the subtypes which exhibit rapid desensitization (GluR4 and 2/3). In the auditory brainstem, levels of GluR2/3 and GluR4 were very high in the cochlear nucleus magnocellularis and the nucleus laminaris. The different cell types of the cochlear nucleus angularis and the superior olive were characterized by heterogeneous GluR2/3 and 4 immunostaining. GluR1 levels were very low or undetectable. In the lemniscal nuclei, most neurons contained low levels of GluR1, and dense GluR2/3 and GluR4 immunoreactivity, with high levels of GluR4 in the dendrites. Levels of GluR4 were higher in the anterior portion of the ventral nucleus of the lateral lemniscus. The divisions of the inferior colliculus could be distinguished on the basis of GluR1–4 immunoreactivity, with high levels of GluR4 and moderate levels of GluR1 in the external nucleus. No major differences were observed between the pathways for encoding time and sound level cues. en
dc.language Eng en
dc.relation.ispartofseries Journal of Comparative Neurology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0021-9967/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject excitatory amino acids en
dc.subject glutamate receptor subunits en
dc.subject central auditory system en
dc.subject AVIAN COCHLEAR NUCLEUS en
dc.subject DIFFERENTIAL EXPRESSION PATTERNS en
dc.subject INTERAURAL TIME DIFFERENCES en
dc.subject D-ASPARTATE RECEPTORS en
dc.subject RAT-BRAIN en
dc.subject SYNAPTIC TRANSMISSION en
dc.subject INFERIOR COLLICULUS en
dc.subject MESSENGER-RNAS en
dc.subject NEURAL MAP en
dc.subject SUPERIOR OLIVE en
dc.title Localization of AMPA-selective glutamate receptors in the auditory brainstem of the barn owl en
dc.type Journal Article en
dc.identifier.doi 10.1002/(SICI)1096-9861(19970210)378:2<239::AID-CNE7>3.0.CO;2-4 en
pubs.issue 2 en
pubs.begin-page 239 en
pubs.volume 378 en
dc.rights.holder Copyright: 1997 Wiley-Liss, Inc. en
dc.identifier.pmid 9120063 en
pubs.end-page 253 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 37245 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Anatomy and Medical Imaging en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 9120063 en


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