Using Physiome standards to couple cellular functions for cardiac excitation-contraction

Show simple item record Terkildsen, Jonna en Niederer, S en Crampin, Edmund en Hunter, Peter en Smith, Nicolas en 2011-08-16T03:31:24Z en 2008 en
dc.identifier.citation Exp Physiol 93(7):919-929 Jul 2008 en
dc.identifier.issn 0958-0670 en
dc.identifier.uri en
dc.description.abstract Scientific endeavour is reliant upon the extension and reuse of previous knowledge. The formalization of this process for computational modelling is facilitated by the use of accepted standardswithwhich to describe and simulatemodels, ensuring consistency between themodels and thus reducing the development and propagation of errors. CellML 1.1, an XML-based programming language, has been designed as a modelling standard which, by virtue of its import and grouping functions, facilitates model combination and reuse. Using CellML 1.1, we demonstrate the process of formalized model reuse by combining three separate models of rat cardiomyocyte function (an electrophysiology model, amodel of cellular calcium dynamics and a mechanics model) which together make up the Pandit–Hinch–Niederer et al. cell model. Not only is this integrative model of rat electromechanics a useful tool for cardiac modelling but it is also an ideal framework with which to demonstrate both the power of model reuse and the challenges associated with this process. We highlight and classify a number of these issues associated with combining models and provide some suggested solutions. en
dc.language EN en
dc.relation.ispartofseries Experimental Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject CELLML en
dc.subject RELAXATION en
dc.title Using Physiome standards to couple cellular functions for cardiac excitation-contraction en
dc.type Journal Article en
dc.identifier.doi 10.1113/expphysiol.2007.041871 en
pubs.issue 7 en
pubs.begin-page 919 en
pubs.volume 93 en
dc.rights.holder Copyright: 2008 The Authors. Journal compilation; 2008 The Physiological Society en
dc.identifier.pmid 18344258 en
pubs.end-page 929 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 91326 en Bioengineering Institute en ABI Associates en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18344258 en

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