dc.contributor.author |
Terkildsen, Jonna |
en |
dc.contributor.author |
Niederer, S |
en |
dc.contributor.author |
Crampin, Edmund |
en |
dc.contributor.author |
Hunter, Peter |
en |
dc.contributor.author |
Smith, Nicolas |
en |
dc.date.accessioned |
2011-08-16T03:31:24Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Exp Physiol 93(7):919-929 Jul 2008 |
en |
dc.identifier.issn |
0958-0670 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/7361 |
en |
dc.description.abstract |
Scientific endeavour is reliant upon the extension and reuse of previous knowledge. The formalization of this process for computational modelling is facilitated by the use of accepted standardswithwhich to describe and simulatemodels, ensuring consistency between themodels and thus reducing the development and propagation of errors. CellML 1.1, an XML-based programming language, has been designed as a modelling standard which, by virtue of its import and grouping functions, facilitates model combination and reuse. Using CellML 1.1, we demonstrate the process of formalized model reuse by combining three separate models of rat cardiomyocyte function (an electrophysiology model, amodel of cellular calcium dynamics and a mechanics model) which together make up the Pandit–Hinch–Niederer et al. cell model. Not only is this integrative model of rat electromechanics a useful tool for cardiac modelling but it is also an ideal framework with which to demonstrate both the power of model reuse and the challenges associated with this process. We highlight and classify a number of these issues associated with combining models and provide some suggested solutions. |
en |
dc.language |
EN |
en |
dc.relation.ispartofseries |
Experimental Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0958-0670/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
VENTRICULAR MYOCYTES |
en |
dc.subject |
MATHEMATICAL-MODEL |
en |
dc.subject |
CELLML |
en |
dc.subject |
RELAXATION |
en |
dc.title |
Using Physiome standards to couple cellular functions for cardiac excitation-contraction |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1113/expphysiol.2007.041871 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
919 |
en |
pubs.volume |
93 |
en |
dc.rights.holder |
Copyright: 2008 The Authors. Journal compilation; 2008 The Physiological Society |
en |
dc.identifier.pmid |
18344258 |
en |
pubs.end-page |
929 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
91326 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18344258 |
en |