dc.contributor.author |
Nickerson, David |
en |
dc.contributor.author |
Nash, Martyn |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.author |
Smith, N |
en |
dc.contributor.author |
Hunter, Peter |
en |
dc.date.accessioned |
2011-08-16T03:33:22Z |
en |
dc.date.issued |
2006 |
en |
dc.identifier.citation |
IBM Journal of Research and Development 50(6):617-630 2006 |
en |
dc.identifier.issn |
0018-8646 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/7369 |
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dc.description.abstract |
We present a computational modeling and numerical simulation framework that enables the integration of multiple physics and spatiotemporal scales in models of physiological systems. This framework is the foundation of the IUPS (International Union of Physiological Sciences) Physiome Project. One novel aspect is the use of CellML, an annotated mathematical representation language, to specify model- and simulation-specific equations. Models of cardiac electromechanics at the cellular, tissue, and organ spatial scales are outlined to illustrate the development and implementation of the framework. We quantify the computational demands of performing simulations using such models and compare models of differing biophysical detail. Applications to other physiological systems are also discussed. |
en |
dc.format.medium |
6 |
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dc.relation.ispartofseries |
IBM Journal of Research and Development |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Medical computing Physiology Large scale systems Mathematical models Computer simulation Cardiac electromechanics Mathematical representation language Computational modeling 723.5 Computer Applications 461.1 Biomedical Engineering 461.9 Biology 921.6 Numerical Methods |
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dc.title |
Computational multiscale modeling in the IUPS Physiome Project: modeling cardiac electromechanics |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1147/rd.506.0617 |
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pubs.begin-page |
617 |
en |
pubs.volume |
50 |
en |
dc.rights.holder |
Copyright: 2006 IBM. |
en |
pubs.author-url |
http://domino.research.ibm.com/tchjr/journalindex.nsf/a3807c5b4823c53f85256561006324be/80daf010ba72d2c48525720c007aef24?OpenDocumenthttp://www.research.ibm.com/journal/rd/506/nickerson.pdf |
en |
pubs.end-page |
630 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
JOUR |
en |
pubs.elements-id |
92334 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |