Mathematical modelling of the ischaemic heart

Abstract

Recent advances in high performance computing combined with increasing knowledge of the kinetics of biochemical reactions and transport processes have allowed us to develop mathematical models that describe various aspects of cardiac physiology. These models include both single cell and three-dimensional tissue models that simulate important features of cardiac electrophysiology, mechanics, and metabolism. We have begun to couple these models with the goal of creating a fully integrated cardiac model that can describe the pathophysiology of the ischaemic heart. Here we present an outline of this work.