The Cardiac Physiome: at the heart of coupling models to measurement

Abstract

Over the last two decades, technical breakthroughs in experimental physiology have paved the way for an explosion in the quality and quantity of data available for analysis. These developments have underpinned many of the postgenomic era’s advances, through the collection of individual data sets frommany species, including humans. In parallelwith these experimental developments, advances in computing and numerical techniques have accelerated our capacity to handle large volumes of data, making possible the integration of these data sets through the application of biophysically based, computational models.