Multiscale Modelling of Intracranial Aneurysms: Cell Signalling, Hemodynamics and Remodelling

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dc.contributor.author Suresh, VA en
dc.contributor.author Ho, H en
dc.contributor.author Kang, W en
dc.contributor.author Cooling, Michael en
dc.contributor.author Watton, PN en
dc.contributor.author Hunter, Peter en
dc.contributor.editor Dhawan, A en
dc.date.accessioned 2011-09-04T21:11:49Z en
dc.date.issued 2011-10 en
dc.identifier.citation IEEE Transactions on Biomedical Engineering 58(10):2974-2977 Oct 2011 en
dc.identifier.issn 0018-9294 en
dc.identifier.uri http://hdl.handle.net/2292/7562 en
dc.description.abstract The genesis, growth and rupture of intracranial aneurysms (IAs) involves physics at the molecular, cellular, blood vessel and organ levels that occurs over time scales ranging from seconds to years. Comprehensive mathematical modelling of IAs therefore requires the description and integration of events across length and time scales that span many orders of magnitude. In this letter we outline a strategy for mulstiscale modelling of IAs that involves the construction of individual models at each relevant scale and their subsequent combination into an integrative model that captures the overall complexity of IA development. An example of the approach is provided using three models operating at different length and time scales: (1) shear stress induced nitric oxide production; (2) smooth muscle cell apoptosis; and (3) fluid-structure-growth modelling. A computational framework for combining them is presented. We conclude with a discussion of the advantages and challenges of the approach. en
dc.relation.ispartofseries IEEE Transactions on Biomedical Engineering en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0018-9294/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Multiscale Modelling of Intracranial Aneurysms: Cell Signalling, Hemodynamics and Remodelling en
dc.type Journal Article en
dc.identifier.doi 10.1109/TBME.2011.2160638 en
dc.rights.holder Copyright: 2011 IEEE en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Letter en
pubs.elements-id 216284 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2011-08-03 en


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