Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function

Show simple item record Wang, Yang en Lam, Hoi en Ennis, DB en Cowan, Brett en Young, Alistair en Nash, Martyn en
dc.coverage.spatial New York, NY en 2011-09-06T02:10:03Z en 2009 en
dc.identifier.citation Med Image Anal 13(5):773-784 Oct 2009 en
dc.identifier.issn 1361-8415 en
dc.identifier.uri en
dc.description.abstract The majority of patients with clinically diagnosed heart failure have normal systolic pump function and are commonly categorized as suffering from diastolic heart failure. The left ventricle (LV) remodels its structure and function to adapt to pathophysiological changes in geometry and loading conditions, which in turn can alter the passive ventricular mechanics. In order to better understand passive ventricular mechanics, a LV finite element (FE) model was customized to geometric data segmented from in vivo tagged magnetic resonance images (MRI) data and myofibre orientation derived from ex vivo diffusion tensor MRI (DTMRI) of a canine heart using nonlinear finite element fitting techniques. MRI tissue tagging enables quantitative evaluation of cardiac mechanical function with high spatial and temporal resolution, whilst the direction of maximum water diffusion in each voxel of a DTMRI directly corresponds to the local myocardial fibre orientation. Due to differences in myocardial geometry between in vivo and ex vivo imaging, myofibre orientations were mapped into the geometric FE model using host mesh fitting (a free form deformation technique). Pressure recordings, temporally synchronized to the tagging data, were used as the loading constraints to simulate the LV deformation during diastole. Simulation of diastolic LV mechanics allowed us to estimate the stiffness of the passive LV myocardium based on kinematic data obtained from tagged MRI. Integrated physiological modelling of this kind will allow more insight into mechanics of the LV on an individualized basis, thereby improving our understanding of the underlying structural basis of mechanical dysfunction under pathological conditions. en
dc.language EN en
dc.publisher Elsevier B.V. en
dc.relation.ispartofseries Medical Image Analysis en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Cardiac magnetic resonance imaging (MRI) en
dc.subject Diffusion tensor MRI (DTMRI) en
dc.subject Left ventricular (LV) mechanics en
dc.subject Finite element modelling en
dc.subject Material parameter estimation en
dc.subject SIMPLE SHEAR en
dc.subject HEART en
dc.subject MYOCARDIUM en
dc.subject STRESS en
dc.subject STRAIN en
dc.subject ARCHITECTURE en
dc.title Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function en
dc.type Journal Article en
dc.identifier.doi 10.1016/ en
pubs.issue 5 en
pubs.begin-page 773 en
pubs.volume 13 en
dc.rights.holder Copyright: 2009 Elsevier B.V. en
dc.identifier.pmid 19664952 en
pubs.end-page 784 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 94109 en Bioengineering Institute en ABI Associates en Engineering en Engineering Science en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19664952 en

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