dc.contributor.author |
Gueret, Stephanie |
en |
dc.contributor.author |
Choi, Ka |
en |
dc.contributor.author |
O'Connor, Patrick |
en |
dc.contributor.author |
Boyd, Peter |
en |
dc.contributor.author |
Brimble, Margaret |
en |
dc.date.accessioned |
2011-09-06T02:21:00Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Acta Crystallographica Section E-Structure Reports E64(6):o1151-o1151 2008 |
en |
dc.identifier.issn |
1600-5368 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/7738 |
en |
dc.description.abstract |
The crystal structure of the title compound, C12H21NO, has been investigated to establish the absolute stereochemistry at position 1. The absolute stereochemistry at the quaternary centre at position 6 is established to be R using an asymmetric Birch reductive alkylation reaction for which the stereochemical outcome is known. The crystal structure indicates the presence of two conformers of the bicyclic (1R,6R)-spirolactam ring system that differ in the conformation adopted by the six-membered ring. In one conformer, the methyl group adopts an axial position whereas in the other conformer, the same methyl group adopts an equatorial position. In both conformers, the seven-membered ring adopts a chair conformation. The two conformers of the bicyclic spirolactam are connected to each other via intermolecular N-HO hydrogen bonds forming a heterodimer. The asymmetric unit contains two such dimers. |
en |
dc.language |
EN |
en |
dc.publisher |
International Union of Crystallography |
en |
dc.relation.ispartofseries |
Acta Crystallographica Section E-Structure Reports |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1600-5368/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://journals.iucr.org/services/copyrightpolicy.html |
en |
dc.subject |
SPIROLIDE-C |
en |
dc.subject |
OSTENFELDII |
en |
dc.subject |
ALKYLATION |
en |
dc.title |
(1R,6R)-1-methyl-8-azaspiro[5.6]dodecan-7one |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1107/S1600536808015158 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
o1151 |
en |
pubs.volume |
E64 |
en |
dc.rights.holder |
Copyright: International Union of Crystallography |
en |
dc.identifier.pmid |
21202659 |
en |
pubs.end-page |
o1151 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
79474 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
21202659 |
en |