The architecture of the heart: a data-based model

Abstract

An appropriate mathematical representation of heart structure is central to advancing an integrative approach to cardiac function. The Auckland heart model provides a realistic representation of important aspects of ventricular structure. The finite–element model is based on extensive anatomical data and incorporates detailed information on ventricular geometry and myocyte organization. It includes preliminary descriptions of the Purkinje fibre network, coronary vessels and collagen organization. Comprehensive extension of these data is required to exploit the full potential of computer modelling. In particular, we need to quantify the morphology of the atria, cardiac conduction system and the intramyocardial coronary vessels. This information must span an appropriate range of species and disease states.