dc.contributor.author |
Van Beek, JH |
en |
dc.contributor.author |
Loiselle, Denis |
en |
dc.contributor.author |
Westerhof, N |
en |
dc.date.accessioned |
2011-09-06T03:37:28Z |
en |
dc.date.issued |
1992 |
en |
dc.identifier.citation |
American Journal of Physiology 263(4):H1003-H1010 Oct 1992 |
en |
dc.identifier.issn |
0363-6135 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/7790 |
en |
dc.description.abstract |
Although exact mathematical descriptions of oxygen diffusion into unperfused isolated organs are known, no analytic solution is available for perfused organs. Here, we derive an equation for oxygen diffusion across the epicardial surface of perfused hearts. Our oxygen transport model incorporates oxygen delivery from the capillary perfusate, oxygen consumption, diffusion among adjacent capillary exchange regions, and diffusion across the epicardial surface. The wall of the heart is modeled by a slab of tissue. The derived equation fits experimental data on the diffusive oxygen flux across the surface of isolated saline-perfused guinea pig hearts, obtained by measuring oxygen uptake from the perfusate at various oxygen tensions in the surroundings of the isolated heart. The model predicts that in isolated arrested guinea pig hearts suspended in air, 25% of the oxygen taken up from the saline perfusate (PO2 approximately 680 mmHg) diffuses out of the heart across the surface. In beating isolated guinea pig hearts, 5% of the oxygen taken up from the perfusate diffuses across the surface. |
en |
dc.language |
EN |
en |
dc.relation.ispartofseries |
American Journal of Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0363-6135/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
MYOCARDIAL OXYGEN CONSUMPTION |
en |
dc.subject |
OXYGEN TRANSPORT EQUATION |
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dc.subject |
EPICARDIAL EXCHANGE |
en |
dc.subject |
MATHEMATICAL MODEL |
en |
dc.subject |
TISSUE OXYGEN TENSION |
en |
dc.subject |
GUINEA PIG |
en |
dc.subject |
TEMPERATURE DISTRIBUTION |
en |
dc.subject |
SKELETAL-MUSCLE |
en |
dc.subject |
HETEROGENEITY |
en |
dc.subject |
TRANSPORT |
en |
dc.subject |
STATE |
en |
dc.subject |
CONSUMPTION |
en |
dc.subject |
MYOCARDIUM |
en |
dc.subject |
NETWORKS |
en |
dc.subject |
TISSUE |
en |
dc.subject |
MODEL |
en |
dc.title |
Calculation of oxygen diffusion across the surface of isolated perfused hearts |
en |
dc.type |
Journal Article |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
H1003 |
en |
pubs.volume |
263(4 pt2) |
en |
dc.rights.holder |
Copyright: 1992 the American Physiological Society |
en |
pubs.end-page |
H1010 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
63183 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |