dc.contributor.author |
Taberner, Andrew |
en |
dc.contributor.author |
Hunter, IW |
en |
dc.contributor.author |
Kirton, RS |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.author |
Loiselle, Denis |
en |
dc.date.accessioned |
2011-09-06T03:54:58Z |
en |
dc.date.issued |
2005 |
en |
dc.identifier.citation |
Review of Scientific Instruments 76(10): Article number 104902 Oct 2005 |
en |
dc.identifier.issn |
0034-6748 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/7800 |
en |
dc.description.abstract |
The energy consumption of isolated cardiac trabeculae can be inferred from measurements of their heat production. Once excised from the heart, to remain viable, trabeculae require continuous superfusion with an oxygen- and nutrient-rich solution. Flow-through calorimeters enable trabeculae to be maintained in a stable and controlled environment for many hours at a time. In this paper we describe and characterize a flow-through microcalorimeter, with sensitivity in the 1 mu W range, for measuring the heat output of 10 mu g cardiac trabeculae. The device uses infrared-sensitive, thin-film thermopile sensors to provide a noncontact method for measuring temperature differences. The sensors are capable of resolving 5 mu K temperature differences within the superfusing fluid. The microcalorimeter has a sensitivity of 2.56 V/W at a flow rate of 1 mu l/s, with a time constant of approximately 3.5 s. The sensitivity and time constant are strongly dependent upon the flow rate. Predictions of a finite-element model of the calorimeter's characteristics compare favorably with measured data over a wide range of flow rates. (c) 2005 American Institute of Physics. |
en |
dc.format.medium |
10 |
en |
dc.relation.ispartofseries |
Review of Scientific Instruments |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0034-6748/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Calorimeters Cardiology Finite element method Mathematical models Sensors Thermal effects Thin filmscardiology calorimeters biothermics thermopiles temperature sensors finite element analysis |
en |
dc.title |
Characterization of a flow-through microcalorimeter for measuring the heat production of cardiac trabeculae |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1063/1.2093769 |
en |
pubs.begin-page |
104902 |
en |
pubs.volume |
76 |
en |
dc.rights.holder |
Copyright: 2005 American Institute of Physics. |
en |
pubs.author-url |
http://link.aip.org/link/?RSI/76/104902/1http://dx.doi.org/10.1063/1.2093769%3CGo%20to%20ISI%3E://000232855900030 |
en |
pubs.end-page |
104908 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
JOUR |
en |
pubs.elements-id |
53596 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |