Simultaneous heat and fluorescence changes in cardiac muscle at high rates of energy expenditure: effects of caffeine and isoprenaline

Show simple item record Chapman, John en Gibbs, CL en Loiselle, Denis en 2011-09-06T21:38:59Z en 1977 en
dc.identifier.citation Journal of Molecular and Cellular Cardiology 90(9):715-732 1977 en
dc.identifier.issn 0022-2828 en
dc.identifier.uri en
dc.description.abstract The relationship between the fluorescence-time integral and heat production was investigated in isolated rabbit papillary muscles at room temperature. Four treatments were used: (1) control; (2) 10−3 m caffeine; (3) 5×10−3m caffeine; (4) 5×10−3 m caffeine +2×10−7m isoprenaline. The first two treatments were associated with low rates of energy expenditure for a given rate of stimulation whereas high rates of energy turnover occurred with the last two treatments. The enthalpy versus load relationship was studied in each treatment as a means for obtaining plots of fluorescence-time integral versus active heat production. All the plots showed high correlations between the two parameters but the linearity of the relationship broke down at high rates of energy expenditure, associated with treatments (3) and (4), as complexities arose in the fluorescence waveforms. No significant changes in resting heat production were induced by any of the drug treatments. Although the mechanical work output was much higher in treatments (3) and (4), the associated extra-active heat production was sufficient to cause a marked drop in mechanical efficiency. Possible biochemical mechanisms underlying the results are discussed. en
dc.relation.ispartofseries Journal of Molecular and Cellular Cardiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Simultaneous heat and fluorescence changes in cardiac muscle at high rates of energy expenditure: effects of caffeine and isoprenaline en
dc.type Journal Article en
dc.identifier.doi 10.1016/S0022-2828(77)80018-7 en
pubs.issue 9 en
pubs.begin-page 715 en
pubs.volume 90 en
dc.rights.holder Copyright: 1977 Elsevier Ltd. en
dc.identifier.pmid 903979 en
pubs.end-page 732 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 63324 en Bioengineering Institute en ABI Associates en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 903979 en

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