Stretch-induced increase in resting metabolism of isolated papillary muscle

Show simple item record Loiselle, Denis en 2011-09-06T21:39:18Z en 1982 en
dc.identifier.citation Biophysical Journal 38 (2):185-194 1982 en
dc.identifier.issn 0006-3495 en
dc.identifier.uri en
dc.description.abstract A mathematical model of oxygen diffusion into quiescent papillary muscles in vitro is developed. The model incorporates a continuous sigmoidal function relating the rate of oxygen consumption and the partial pressure of oxygen within the tissue. The behavior of the model is explored over a wide range of external oxygen partial pressures, oxygen consumption/partial pressure relations, oxygen diffusivities, muscle dimensions, and resting metabolic rates, while the muscle is subjected to simulated stretches of various extents in order to test the assertion that the stretch-induced increase in basal metabolic rate observed experimentally implies the existence of an anoxic core region of papillary muscles in vitro. The model predicts the existence of an oxygen diffusion-mediated stretch response of resting papillary muscle metabolism, but one which is quantitatively insignificant compared with experimentally observed values. The classic Hill diffusion model, which explicitly predicts an anoxic core, likewise predicts stretch effects of magnitudes smaller than those frequently observed. It is concluded that the increment in basal metabolism of papillary muscles subjected to stretch in vitro cannot be taken as evidence of oxygen diffusion limitation in unstretched preparations. en
dc.relation.ispartofseries Biophysical Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Stretch-induced increase in resting metabolism of isolated papillary muscle en
dc.type Journal Article en
pubs.begin-page 185 en
pubs.volume 38 (2) en
dc.rights.holder Copyright: Biophysical Society en
dc.identifier.pmid 7093421 en
pubs.end-page 194 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 63255 en Bioengineering Institute en ABI Associates en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 7093421 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace