dc.contributor.author |
Taberner, AJ |
en |
dc.contributor.author |
Han, June |
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dc.contributor.author |
Kirton, Robert |
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dc.contributor.author |
Loiselle, Denis |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.editor |
Armentano, R |
en |
dc.contributor.editor |
Hudson, D |
en |
dc.contributor.editor |
Monzon, J |
en |
dc.contributor.editor |
Patton, J |
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dc.date.accessioned |
2011-09-06T21:39:23Z |
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dc.date.issued |
2010 |
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dc.identifier.citation |
Conf Proc IEEE Eng Med Biol Soc 2010:1860-1863 2010 |
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dc.identifier.isbn |
9781424441242 |
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dc.identifier.uri |
http://hdl.handle.net/2292/7823 |
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dc.description.abstract |
Progress toward understanding the thermo-mechanical behavior of isolated cardiac muscle, excised from either healthy or diseased heart, is contingent on being able to measure simultaneously the stress (force per cross- sectional area) and heat production. Determination of dynamic modulus (dynamic stiffness times muscle length per cross- sectional area) sheds further light on the behavior of the force- and heat-generating actin-myosin cross-bridges. We are in a unique position to perform such measurements, given the recent completion of a micro-mechano-calorimeter. In this paper, we characterize the micro-mechano-calorimeter and present experimental results of twitch stress, heat per twitch and dynamic modulus measured in rat right-ventricular trabeculae at varied stimulus frequencies and muscle lengths. The minute radial dimensions of cardiac trabeculae (which approximate those of a human hair) ensure adequate provision of oxygen and nutrients via diffusion from the continuously replenished superfusate flowing through the measurement chamber. This enables investigation of the thermo-mechanical performance of cardiac trabeculae for many hours. |
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dc.relation.ispartof |
32nd Annual Conference of the IEEE Engineering in Medicine and Biology Society |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
Stress development, heat production and dynamic modulus of rat isolated cardiac trabeculae revealed in a flow-through micro-mechano-calorimeter |
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dc.type |
Conference Item |
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pubs.begin-page |
1860 |
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dc.rights.holder |
Copyright: 2010 IEEE |
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dc.identifier.pmid |
21095942 |
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pubs.end-page |
1863 |
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pubs.place-of-publication |
Buenos Aires |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
190928 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2011-02-07 |
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pubs.dimensions-id |
21095942 |
en |