Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?

Mitsakos, V; Dobson, Renwick; Pearce, FG; Devenish, SR; Evans, Genevieve; Burgess, BR; Perugini, MA; Gerrard, Juliet; Hutton, CA

dc.contributor.author	Mitsakos, V	en
dc.contributor.author	Dobson, Renwick	en
dc.contributor.author	Pearce, FG	en
dc.contributor.author	Devenish, SR	en
dc.contributor.author	Evans, Genevieve	en
dc.contributor.author	Burgess, BR	en
dc.contributor.author	Perugini, MA	en
dc.contributor.author	Gerrard, Juliet	en
dc.contributor.author	Hutton, CA	en
dc.date.accessioned	2011-09-07T01:23:37Z	en
dc.date.issued	2008-01-15	en
dc.identifier.citation	BIOORG MED CHEM LETT 18(2):842-844 15 Jan 2008	en
dc.identifier.issn	0960-894X	en
dc.identifier.uri	http://hdl.handle.net/2292/7846	en
dc.description.abstract	Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable.	en
dc.language	EN	en
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
dc.relation.ispartofseries	BIOORG MED CHEM LETT	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0960-894X/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	N-ACETYLNEURAMINATE LYASE	en
dc.subject	ESCHERICHIA-COLI	en
dc.subject	MECHANISM	en
dc.subject	EXPRESSION	en
dc.subject	CLONING	en
dc.subject	LYSINE	en
dc.title	Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.bmcl.2007.11.026	en
pubs.issue	2	en
pubs.begin-page	842	en
pubs.volume	18	en
dc.rights.holder	Copyright: 2007 Elsevier Ltd.	en
dc.identifier.pmid	18054225	en
pubs.end-page	844	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	188841	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.record-created-at-source-date	2011-10-25	en
pubs.dimensions-id	18054225	en