Natural products targeting telomere maintenance

Chen, JLY; Sperry, Jonathan; Ip, NY; Brimble, Margaret

dc.contributor.author	Chen, JLY	en
dc.contributor.author	Sperry, Jonathan	en
dc.contributor.author	Ip, NY	en
dc.contributor.author	Brimble, Margaret	en
dc.date.accessioned	2011-09-18T21:36:26Z	en
dc.date.issued	2011	en
dc.identifier.citation	Med. Chem. Commun. 2011(2):229-245 2011	en
dc.identifier.issn	2040-2503	en
dc.identifier.uri	http://hdl.handle.net/2292/7973	en
dc.description.abstract	Telomeres are repetitive sequences of DNA found at the ends of chromosomes which determine and restrict the number of replications a cell can undertake. In the majority of cancer cells, telomerase has been found to maintain the length of telomeres, conferring cell immortality and prevention of cell senescence. With the ready availability of assays to detect telomerase activity, numerous telomerase inhibitors have been discovered from a variety of natural sources. This article gives an outline of these natural product-based telomerase inhibitors and their inspiration for analogue design.	en
dc.language	EN	en
dc.publisher	ROYAL SOC CHEMISTRY	en
dc.relation.ispartofseries	Med. Chem. Commun.	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2040-2503/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	QUADRUPLEX STABILIZING LIGANDS	en
dc.subject	GREEN TEA POLYPHENOLS	en
dc.subject	LEUKEMIA HL-60 CELLS	en
dc.subject	CANCER-CELLS	en
dc.subject	IN-VITRO	en
dc.subject	INDUCED APOPTOSIS	en
dc.subject	ANTITUMOR AGENTS	en
dc.subject	GAMBOGIC ACID	en
dc.subject	REVERSE-TRANSCRIPTASE	en
dc.subject	BERBERINE DERIVATIVES	en
dc.title	Natural products targeting telomere maintenance	en
dc.type	Journal Article	en
dc.identifier.doi	10.1039/c0md00241k	en
pubs.issue	2	en
pubs.begin-page	229	en
pubs.volume	2011	en
dc.rights.holder	Copyright: 2011 The Royal Society of Chemistry	en
pubs.end-page	245	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.subtype	Review	en
pubs.elements-id	210460	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2011-06-30	en