A One-pot Approach to Neoglycopeptides using Orthogonal Native Chemical Ligation and Click Chemistry

Lee, Dong; Mandal, K; Harris, Paul; Brimble, Margaret; Kent, Stephen

dc.contributor.author	Lee, Dong	en
dc.contributor.author	Mandal, K	en
dc.contributor.author	Harris, Paul	en
dc.contributor.author	Brimble, Margaret	en
dc.contributor.author	Kent, Stephen	en
dc.date.accessioned	2011-09-18T23:29:14Z	en
dc.date.issued	2009	en
dc.identifier.citation	Organic Letters 11(22):5270-5273 2009	en
dc.identifier.issn	1523-7060	en
dc.identifier.uri	http://hdl.handle.net/2292/8015	en
dc.description.abstract	The powerful combination of native chemical ligation and click chemistry has been used to affect a one-pot synthesis of neoglycopeptides from propargyl-containing peptides using GalNAc-N3 as the glycan component. A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is thus demonstrated.	en
dc.language	EN	en
dc.publisher	American Chemical Society	en
dc.relation.ispartofseries	Organic Letters	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1523-7060/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	AZIDE	en
dc.subject	CYCLOADDITION	en
dc.subject	GLYCOPROTEINS	en
dc.subject	GLYCOPEPTIDES	en
dc.subject	PROTEINS	en
dc.subject	TRIAZOLE	en
dc.subject	ALKYNES	en
dc.subject	TOOL	en
dc.title	A One-pot Approach to Neoglycopeptides using Orthogonal Native Chemical Ligation and Click Chemistry	en
dc.type	Journal Article	en
dc.identifier.doi	10.1021/ol902131n	en
pubs.issue	22	en
pubs.begin-page	5270	en
pubs.volume	11	en
dc.rights.holder	Copyright: 2009 American Chemical Society	en
dc.identifier.pmid	19842689	en
pubs.end-page	5273	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	102227	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.dimensions-id	19842689	en