Synthesis of Fish Antifreeze Neoglycopeptides Using Microwave-assisted "Click Chemistry"

Miller, Nicole; Williams, Geoffrey; Brimble, Margaret

dc.contributor.author	Miller, Nicole	en
dc.contributor.author	Williams, Geoffrey	en
dc.contributor.author	Brimble, Margaret	en
dc.date.accessioned	2011-09-19T00:05:00Z	en
dc.date.issued	2009	en
dc.identifier.citation	Organic Letters 11(11):2409-2412 2009	en
dc.identifier.issn	1523-7060	en
dc.identifier.uri	http://hdl.handle.net/2292/8027	en
dc.description.abstract	Microwave-enhanced click glycoconjugation of a propargylated α-GalNAc sugar moiety with an azido-functionalized amino acid or multiazido-functionalized peptides using a catalytic quantity of Cu(I) enabled a high-yielding and rapid synthesis of a “Tn-antigen mimic” and click analogues of antifreeze glycopeptides, thus demonstrating a valuable synthetic platform for the synthesis of biologically relevant neoglycopeptides.	en
dc.language	EN	en
dc.publisher	American Chemical Society	en
dc.relation.ispartofseries	Organic Letters	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1523-7060/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	SELECTIVE GLYCOSYLATION	en
dc.subject	PROTEINS	en
dc.subject	GLYCOPROTEINS	en
dc.subject	CYCLOADDITION	en
dc.subject	ANALOGS	en
dc.subject	ICE	en
dc.title	Synthesis of Fish Antifreeze Neoglycopeptides Using Microwave-assisted "Click Chemistry"	en
dc.type	Journal Article	en
dc.identifier.doi	10.1021/ol9005536	en
pubs.issue	11	en
pubs.begin-page	2409	en
pubs.volume	11	en
dc.rights.holder	Copyright: 2009 American Chemical Society	en
dc.identifier.pmid	19473046	en
pubs.end-page	2412	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	86201	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.dimensions-id	19473046	en