Diastereoselective Synthesis of Substituted 4-Piperidones and 4-Piperidols Using a Double Mannich Reaction

Chan, Y; Guthmann, Holger; Brimble, Margaret; Barker, David

dc.contributor.author	Chan, Y	en
dc.contributor.author	Guthmann, Holger	en
dc.contributor.author	Brimble, Margaret	en
dc.contributor.author	Barker, David	en
dc.date.accessioned	2011-09-19T01:53:35Z	en
dc.date.issued	2008	en
dc.identifier.citation	Synlett 17, 2601-2604, 2008	en
dc.identifier.issn	0936-5214	en
dc.identifier.uri	http://hdl.handle.net/2292/8071	en
dc.description.abstract	A simple and efficient synthesis of polysubstituted 4-piperidones was achieved from the double Mannich reaction of beta-keto esters and bisaminol ethers. The reaction is highly diastereoselective, as is the subsequent hydride reduction, to give polysubstituted 4-piperidols.	en
dc.language	EN	en
dc.publisher	Georg Thieme Verlag Stuttgart New York	en
dc.relation.ispartofseries	Synlett	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0936-5214/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	4-piperidones	en
dc.subject	Mannich reaction	en
dc.subject	multicomponent reaction	en
dc.subject	RING-E ANALOGS	en
dc.subject	ALPHA-3-BETA-4-ASTERISK-NICOTINIC ACETYLCHOLINE-RECEPTORS	en
dc.subject	BETA-KETO-ESTERS	en
dc.subject	2,4-DISUBSTITUTED PIPERIDINES	en
dc.subject	METHYLLYCACONITINE MLA	en
dc.subject	(&/-)-LYSERGIC ACID	en
dc.subject	EFFICIENT SYNTHESIS	en
dc.subject	CONCISE SYNTHESIS	en
dc.subject	CYCLIZATION	en
dc.subject	ALKALOIDS	en
dc.title	Diastereoselective Synthesis of Substituted 4-Piperidones and 4-Piperidols Using a Double Mannich Reaction	en
dc.type	Journal Article	en
dc.identifier.doi	10.1055/s-0028-1083522	en
pubs.issue	17	en
pubs.begin-page	2601	en
pubs.volume	2008	en
dc.rights.holder	Copyright: Georg Thieme Verlag Stuttgart, New York	en
pubs.end-page	2604	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	79362	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en