Improved Synthesis of the Benzyne Precursor 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate

Atkinson, Darcy; Sperry, Jonathan; Brimble, Margaret

dc.contributor.author	Atkinson, Darcy	en
dc.contributor.author	Sperry, Jonathan	en
dc.contributor.author	Brimble, Margaret	en
dc.date.accessioned	2011-09-19T02:25:32Z	en
dc.date.issued	2010	en
dc.identifier.citation	SYNTHESIS-STUTTGART 911-913 Mar 2010	en
dc.identifier.issn	0039-7881	en
dc.identifier.uri	http://hdl.handle.net/2292/8093	en
dc.description.abstract	An alternate procedure for the preparation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate, a coveted benzyne precursor, is described. Modifications to existing methods result in a dramatic reduction in the overall reaction time and eliminate the use of organolithium reagents. This new procedure proceeds in four steps in 81% overall yield from 2-chlorophenol.	en
dc.language	EN	en
dc.publisher	Georg Thieme Verlag Stuttgart New York	en
dc.relation.ispartofseries	Synthesis	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0039-7881/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	benzyne	en
dc.subject	aryne	en
dc.subject	precursor	en
dc.subject	HEXAMETHYLDISILAZANE HMDS	en
dc.subject	PHENOLS	en
dc.subject	SILYLATION	en
dc.subject	ALCOHOLS	en
dc.subject	TRIMETHYLSILYLATION	en
dc.subject	DERIVATIVES	en
dc.subject	EFFICIENT	en
dc.subject	CLEAVAGE	en
dc.subject	TRIFLATE	en
dc.title	Improved Synthesis of the Benzyne Precursor 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate	en
dc.type	Journal Article	en
dc.identifier.doi	10.1055/s-0029-1218631	en
pubs.issue	6	en
pubs.begin-page	911	en
pubs.volume	2010	en
dc.rights.holder	Copyright: Georg Thieme Verlag Stuttgart New York	en
pubs.end-page	913	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	102229	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en