Improved Synthesis of the Benzyne Precursor 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate

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dc.contributor.author Atkinson, Darcy en
dc.contributor.author Sperry, Jonathan en
dc.contributor.author Brimble, Margaret en
dc.date.accessioned 2011-09-19T02:25:32Z en
dc.date.issued 2010 en
dc.identifier.citation SYNTHESIS-STUTTGART 911-913 Mar 2010 en
dc.identifier.issn 0039-7881 en
dc.identifier.uri http://hdl.handle.net/2292/8093 en
dc.description.abstract An alternate procedure for the preparation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate, a coveted benzyne precursor, is described. Modifications to existing methods result in a dramatic reduction in the overall reaction time and eliminate the use of organolithium reagents. This new procedure proceeds in four steps in 81% overall yield from 2-chlorophenol. en
dc.language EN en
dc.publisher Georg Thieme Verlag Stuttgart New York en
dc.relation.ispartofseries Synthesis en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0039-7881/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject benzyne en
dc.subject aryne en
dc.subject precursor en
dc.subject HEXAMETHYLDISILAZANE HMDS en
dc.subject PHENOLS en
dc.subject SILYLATION en
dc.subject ALCOHOLS en
dc.subject TRIMETHYLSILYLATION en
dc.subject DERIVATIVES en
dc.subject EFFICIENT en
dc.subject CLEAVAGE en
dc.subject TRIFLATE en
dc.title Improved Synthesis of the Benzyne Precursor 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate en
dc.type Journal Article en
dc.identifier.doi 10.1055/s-0029-1218631 en
pubs.issue 6 en
pubs.begin-page 911 en
pubs.volume 2010 en
dc.rights.holder Copyright: Georg Thieme Verlag Stuttgart New York en
pubs.end-page 913 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 102229 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en


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