dc.contributor.author |
Gueret, Stephanie |
en |
dc.contributor.author |
Brimble, Margaret |
en |
dc.date.accessioned |
2011-09-19T20:50:01Z |
en |
dc.date.issued |
2010 |
en |
dc.identifier.citation |
Nat Prod Rep 27(9):1350-1366 Sep 2010 |
en |
dc.identifier.issn |
0265-0568 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8123 |
en |
dc.description.abstract |
Spirolides are metabolites of the dinoflagellates Alexandrium ostenfeldii and Alexandrium peruvianum. Spirolides (A-D) were isolated from the digestive glands of contaminated mussels ( Mytilus edulis), scallops (Placopecten magellanicus) and toxic plankton from the east coast of Nova Scotia in Canada. Fourteen members of the spirolide family of marine biotoxins have since been identified from around the world. The relative stereochemistry of these compounds was established via molecular modelling and NMR studies. Related marine toxins containing a spiroimine unit have been classified as fast-acting toxins and the spirolides also target muscarinic and nicotinic acetylcholine receptors and are weak activators of L-type transmembrane Ca2+ channels. The spirolides are macrocycles that are comprised of two parts: a bis-spiroacetal moiety and an unusual 6,7-bicyclic spiroimine. |
en |
dc.language |
EN |
en |
dc.publisher |
ROYAL SOC CHEMISTRY |
en |
dc.relation.ispartofseries |
NAT PROD REP |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0265-0568/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
DINOFLAGELLATE ALEXANDRIUM-OSTENFELDII |
en |
dc.subject |
HARMFUL ALGAL BLOOMS |
en |
dc.subject |
LIQUID-CHROMATOGRAPHY |
en |
dc.subject |
MASS-SPECTROMETRY |
en |
dc.subject |
COASTAL WATERS |
en |
dc.subject |
NEW-ZEALAND |
en |
dc.subject |
PRECHROMATOGRAPHIC OXIDATION |
en |
dc.subject |
QUANTITATIVE-DETERMINATION |
en |
dc.subject |
FLUORESCENCE DETECTION |
en |
dc.subject |
PTYCHODISCUS-BREVIS |
en |
dc.title |
Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1039/c005400n |
en |
pubs.issue |
9 |
en |
pubs.begin-page |
1350 |
en |
pubs.volume |
27 |
en |
dc.rights.holder |
Copyright: 2010 The Royal Society of Chemistry |
en |
dc.identifier.pmid |
20585694 |
en |
pubs.end-page |
1366 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
120144 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2011-06-30 |
en |
pubs.dimensions-id |
20585694 |
en |