dc.contributor.author |
Brimble, MA |
en |
dc.contributor.author |
Muir, Victoria |
en |
dc.contributor.author |
Hopkins, B |
en |
dc.contributor.author |
Bova, S |
en |
dc.date.accessioned |
2011-09-19T21:13:34Z |
en |
dc.date.issued |
2004 |
en |
dc.identifier.citation |
Archive for Organic Chemistry (ARKIVOC) (1): 1-11 2004 |
en |
dc.identifier.issn |
1424-6376 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8134 |
en |
dc.description.abstract |
The rat toxicant norbormide, was synthesized and six stereoisomers of norbormide were isolated and purified by chromatography in order to undertake structure-activity relationship studies with respect to vasorelaxant and vasoconstrictor properties. Isomers V, W and Y behave qualitatively like the isomeric mixture of norbormide isomers showing either vasoconstrictor or vasorelaxant activities. Isomers X and R exhibit vasorelaxant effects only. These results indicate that the selective vasoconstrictor effect is stereospecific thereby suggesting the existence of a norbormide-specific receptor. |
en |
dc.language |
EN |
en |
dc.relation.ispartofseries |
Archive for Organic Chemistry (ARKIVOC) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
norbormide |
en |
dc.subject |
maleimide |
en |
dc.subject |
Diels-Alder reaction |
en |
dc.subject |
rat selective toxicant |
en |
dc.subject |
SELECTIVE RAT TOXICANT |
en |
dc.subject |
RESONANCE SPECTRA |
en |
dc.subject |
CHEMICAL-SHIFTS |
en |
dc.subject |
STEREOCHEMISTRY |
en |
dc.subject |
NORBORNENE |
en |
dc.subject |
ARTERIES |
en |
dc.subject |
RACEMATE |
en |
dc.title |
Synthesis and evaluation of vasoconstrictor and vasorelaxant activity of norbormide isomers |
en |
dc.type |
Journal Article |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
1 |
en |
dc.rights.holder |
Copyright: ARKAT USA, Inc |
en |
pubs.end-page |
11 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
7260 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |