Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid

Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid

Trotter, Nicholas ; Brimble, MA ; Harris, Paul ; Callis, DJ ; Sieg, Frank
Identifier: http://hdl.handle.net/2292/8135
Issue Date: 2005
Reference: Bioorg Med Chem 13(2):501-517 17 Jan 2005
Rights: Copyright: 2004 Elsevier Ltd.
Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

The synthesis of nine GPE* analogues, wherein the alpha-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-L-proline 2 with various analogues of glutamic acid. Pharmacologi

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DOI: 10.1016/j.bmc.2004.10.005
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