Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)

Lai, MYH; Brimble, MA; Callis, DJ; Harris, Paul; Levi, Mark; Sieg, Frank

dc.contributor.author	Lai, MYH	en
dc.contributor.author	Brimble, MA	en
dc.contributor.author	Callis, DJ	en
dc.contributor.author	Harris, Paul	en
dc.contributor.author	Levi, Mark	en
dc.contributor.author	Sieg, Frank	en
dc.date.accessioned	2011-09-19T21:13:52Z	en
dc.date.issued	2005	en
dc.identifier.citation	Bioorg Med Chem 13(2):533-548 17 Jan 2005	en
dc.identifier.issn	0968-0896	en
dc.identifier.uri	http://hdl.handle.net/2292/8138	en
dc.description.abstract	The synthesis of 10 G*PE analogues, wherein the glycine residue has been modified, is described by coupling readily accessible dibenzyl-L-prolyl-L-glutamate 2 with various analogues of glycine. Pharmacological evaluation of the novel compounds was un	en
dc.language	EN	en
dc.relation.ispartofseries	Bioorganic & Medicinal Chemistry	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0968-0896/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	neuroprotective agents	en
dc.subject	peptides	en
dc.subject	glycine	en
dc.subject	GPE	en
dc.subject	GROWTH-FACTOR-I	en
dc.subject	HYPOXIC-ISCHEMIC INJURY	en
dc.subject	N-TERMINAL TRIPEPTIDE	en
dc.subject	IGF-I	en
dc.subject	RAT-BRAIN	en
dc.subject	BINDING-PROTEINS	en
dc.subject	INSULIN	en
dc.subject	RECEPTORS	en
dc.subject	PEPTIDE	en
dc.subject	CNS	en
dc.title	Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.bmc.2004.10.004	en
pubs.issue	2	en
pubs.begin-page	533	en
pubs.volume	13	en
dc.rights.holder	Copyright: 2004 Elsevier Ltd.	en
dc.identifier.pmid	15598574	en
pubs.end-page	548	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	7856	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.dimensions-id	15598574	en