SYNTHESIS OF 2-METHYLPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE

Brimble, Margaret; BRIMBLE, MT; HODGES, R; LANE, GA

SYNTHESIS OF 2-METHYLPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE

Brimble, Margaret ; BRIMBLE, MT ; HODGES, R ; LANE, GA

Identifier: http://hdl.handle.net/2292/8141

Issue Date: 1988-01-01

Reference: AUST J CHEM 41(10):1583-1590 1988

Rights: Copyright: 1988 CSIRO

Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

The synthesis of 2-methylpyrrolo[1,2-a]pyrazin-1(2H)-one (2) present in the insect feeding deterrent peramine (1) through oxidation of the saturated lactam (3) is described. The preparation of the related 6- methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one (12) through a Lewis-acid- catalysed cyclization of the amide acetal (7) is also described.

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