Synthesis of C-2 functionalised 1,6,8-trioxadispiro[4.1.5.3]pentadec-13-enes

Allen, PA; Brimble, Margaret; Fares, FA

dc.contributor.author	Allen, PA	en
dc.contributor.author	Brimble, Margaret	en
dc.contributor.author	Fares, FA	en
dc.date.accessioned	2011-09-19T22:56:09Z	en
dc.date.issued	1998	en
dc.identifier.citation	Journal of the Chemical Society, Perkin Transactions 1 (15): 2403-2411 1998	en
dc.identifier.issn	1470-4358	en
dc.identifier.uri	http://hdl.handle.net/2292/8175	en
dc.description.abstract	The syntheses of bis-spiroacetals 28 and 44, model systems for the tricyclic bis-spiroacetal moiety of the polyether antibiotic epi-17-deoxy-(O-8)-salinomycin 3, are described. Introduction of an aldehyde group at C-2 was necessary for further elaboration of the right hand side of the molecule. It was found that the choice of protecting group on the hydroxymethyl substituent (precursor to an aldehyde group) was crucial to the outcome of the key oxidative cyclisation.	en
dc.language	EN	en
dc.relation.ispartofseries	Journal of the Chemical Society, Perkin Transactions 1	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	POLYETHER ANTIBIOTIC SALINOMYCIN	en
dc.subject	STEREOCONTROLLED TOTAL SYNTHESIS	en
dc.subject	NATURAL-PRODUCTS	en
dc.subject	CHIRAL SYNTHESIS	en
dc.subject	C18-C30 SEGMENTS	en
dc.subject	D-GLUCOSE	en
dc.subject	REARRANGEMENT	en
dc.subject	C10-C17	en
dc.subject	C1-C9	en
dc.title	Synthesis of C-2 functionalised 1,6,8-trioxadispiro[4.1.5.3]pentadec-13-enes	en
dc.type	Journal Article	en
dc.identifier.doi	10.1039/A802490A	en
pubs.issue	15	en
pubs.begin-page	2403	en
dc.rights.holder	Copyright: 1998 The Royal Society of Chemistry	en
pubs.end-page	2411	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	33952	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en