Synthesis of isotopically labelled glycyl-L-prolyl-L-glutamic acid (Glypromate) and derivatives

Harris, Paul; Brimble, Margaret

dc.contributor.author	Harris, Paul	en
dc.contributor.author	Brimble, Margaret	en
dc.date.accessioned	2011-09-19T23:11:46Z	en
dc.date.issued	2006	en
dc.identifier.citation	J LABELLED COMPD RAD 49(6):571-581 May 2006	en
dc.identifier.issn	0362-4803	en
dc.identifier.uri	http://hdl.handle.net/2292/8186	en
dc.description.abstract	The related tripeptides glycyl-l-prolyl-l-glutamic acid (GPE) and glycyl-l-2-methylprolyl-l-glutamic acid (G-2-MePE) were labelled with commercially available [1,2,3,4,5-13C5, 2-15N1]-l-glutamic acid in 3 steps in excellent overall yield with high isotope incorporation. A related cyclic dipeptide was labelled with [2,2-2H2, 2-15N1]glycine giving a mixture of compounds resulting from deuterium scrambling.	en
dc.language	EN	en
dc.publisher	John Wiley & Sons, Ltd.	en
dc.relation.ispartofseries	Journal of Labelled Compounds & Radiopharmaceuticals	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0362-4803/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	GPE	en
dc.subject	neuroprotective	en
dc.subject	H-2-	en
dc.subject	C-13-	en
dc.subject	N-15-amino acids	en
dc.subject	isotope labelling	en
dc.subject	ANALOGS	en
dc.subject	GPE	en
dc.title	Synthesis of isotopically labelled glycyl-L-prolyl-L-glutamic acid (Glypromate) and derivatives	en
dc.type	Journal Article	en
dc.identifier.doi	10.1002/jlcr.1075	en
pubs.issue	6	en
pubs.begin-page	571	en
pubs.volume	49	en
dc.rights.holder	Copyright: 2006 John Wiley & Sons, Ltd.	en
pubs.end-page	581	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	65347	en
pubs.org-id	Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en