tert-Butyl methoxy(2-propynyl)carbamate

Abstract

The general part of the experimental section [1] has been presented elsewhere. Di-tert-butyl dicarbonate (3.60 g, 13.2 mmol) and 4-(dimethylamino)pyridine (84 mg, 0.687 mmol) were added to a solution of amine 1 [2] (1.12 g, 13.2 mmol) in acetonitrile (14 mL) under nitrogen at room temperature and stirred for 21 h. The yellow liquid was concentrated under reduced pressure to generate a yellow oil that was purified by flash chromatography using hexane-diethyl ether (3:2) as eluent to afford the title compound 2 (1.77 g, 73%) as a colourless oil.