dc.contributor.author |
Malmstrom Pendred, Jenny |
en |
dc.contributor.author |
Lovmand, J |
en |
dc.contributor.author |
Kristensen, S |
en |
dc.contributor.author |
Sundh, M |
en |
dc.contributor.author |
Duch, M |
en |
dc.contributor.author |
Sutherland, DS |
en |
dc.date.accessioned |
2011-09-27T01:01:48Z |
en |
dc.date.issued |
2011 |
en |
dc.identifier.citation |
NANO LETT 11(6):2264-2271 Jun 2011 |
en |
dc.identifier.issn |
1530-6984 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8281 |
en |
dc.description.abstract |
The effects of protein type and pattern size on cell adhesion, spreading, and focal adhesion development are studied. Fibronectin and vitronectin patterns from 0.1 to 3 mu m produced by colloidal lithography reveal important differences in how cells adhere to and bridge focal adhesions across protein nanopatterns versus micropatterns. Vinculin and zyxin in focal adhesions but not integrins are seen to bridge ligand gaps. Differences in protein mechanical properties are implicated as important factors in focal adhesion development. |
en |
dc.language |
EN |
en |
dc.publisher |
American Chemical Society |
en |
dc.relation.ispartofseries |
Nano Letters |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1530-6984/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Protein patterns |
en |
dc.subject |
fibronectin |
en |
dc.subject |
vitronectin |
en |
dc.subject |
cell adhesion |
en |
dc.subject |
focal adhesion |
en |
dc.subject |
EARLY MOLECULAR EVENTS |
en |
dc.subject |
CELL-MATRIX ADHESIONS |
en |
dc.subject |
SURFACES |
en |
dc.subject |
BEHAVIOR |
en |
dc.subject |
AREA |
en |
dc.subject |
MECHANOTRANSDUCTION |
en |
dc.subject |
INTERFACES |
en |
dc.subject |
SUBSTRATA |
en |
dc.subject |
PROTEINS |
en |
dc.title |
Focal Complex Maturation and Bridging on 200 nm Vitronectin but Not Fibronectin Patches Reveal Different Mechanisms of Focal Adhesion Formation |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1021/nl200447q |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
2264 |
en |
pubs.volume |
11 |
en |
dc.rights.holder |
Copyright: 2011 American Chemical Society |
en |
dc.identifier.pmid |
21598955 |
en |
pubs.end-page |
2271 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
221677 |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Chemical and Materials Eng |
en |
pubs.record-created-at-source-date |
2011-08-31 |
en |
pubs.dimensions-id |
21598955 |
en |