Enantiomeric Discorhabdin Alkaloids and Establishment of their Absolute Configurations using Theoretical Calculations of Electronic Circular Dichroism Spectra.

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dc.contributor.author Grkovic, Tanja en
dc.contributor.author Ding, Y en
dc.contributor.author Li, XC en
dc.contributor.author Webb, VL en
dc.contributor.author Ferreira, D en
dc.contributor.author Copp, Brent en
dc.date.accessioned 2011-10-25T01:50:45Z en
dc.date.issued 2008 en
dc.identifier.citation The Journal of Organic Chemistry 73(22):9133-9136 2008 en
dc.identifier.issn 0022-3263 en
dc.identifier.uri http://hdl.handle.net/2292/8364 en
dc.description.abstract Enantiomeric pairs of the cytotoxic pyrroloiminoquinone marine alkaloids discorhabdins B (2), G*/I (3), L (4), and W (5) have been isolated from Latrunculia species sponges collected at different locations around the coast of New Zealand. The absolute configuration of all compounds was secured by comparison of observed data with the results of time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) spectra. Enantiomeric discorhabdins exhibit equipotent antiproliferative biological activity. en
dc.language EN en
dc.publisher American Chemical Society en
dc.relation.ispartofseries Journal of Organic Chemistry en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3263/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject OKINAWAN MARINE SPONGE en
dc.subject GENUS LATRUNCULIA en
dc.subject OPTICAL-ROTATION en
dc.subject PYRROLOIMINOQUINONE en
dc.subject METABOLITES en
dc.title Enantiomeric Discorhabdin Alkaloids and Establishment of their Absolute Configurations using Theoretical Calculations of Electronic Circular Dichroism Spectra. en
dc.type Journal Article en
dc.identifier.doi 10.1021/jo801622n en
pubs.issue 22 en
pubs.begin-page 9133 en
pubs.volume 73 en
dc.rights.holder Copyright: AMER CHEMICAL SOC en
dc.identifier.pmid 18855481 en
pubs.end-page 9136 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 79883 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18855481 en


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