dc.contributor.author |
Pearce, Allison |
en |
dc.contributor.author |
Chia, EW |
en |
dc.contributor.author |
Berridge, MV |
en |
dc.contributor.author |
Clark, George |
en |
dc.contributor.author |
Harper, JL |
en |
dc.contributor.author |
Larsen, L |
en |
dc.contributor.author |
Maas, E |
en |
dc.contributor.author |
Page, MJ |
en |
dc.contributor.author |
Perry, NB |
en |
dc.contributor.author |
Webb, VL |
en |
dc.contributor.author |
Copp, Brent |
en |
dc.date.accessioned |
2011-10-25T01:51:09Z |
en |
dc.date.issued |
2007 |
en |
dc.identifier.citation |
Journal of Natural Products 70(6):936-940 2007 |
en |
dc.identifier.issn |
0163-3864 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8366 |
en |
dc.description.abstract |
Ascidiathiazones A (3) and B (4), two new tricyclic thiazine-containing quinolinequinone alkaloids, were isolated from the New Zealand ascidian Aplidium species. Both compounds inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner with IC50 1.55 ± 0.32 and 0.44 ± 0.09 μM, respectively. In vivo inhibition of superoxide production by peritoneal neutrophils in a murine model of gout was observed for both compounds with oral doses of 25.6 μmol/kg. Ascidiathiazone A (3) was synthesized in four steps from 8-hydroxyquinoline-2-carboxylic acid. |
en |
dc.language |
EN |
en |
dc.publisher |
American Chemical Society and American Society of Pharmacognosy |
en |
dc.relation.ispartofseries |
Journal of Natural Products |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0163-3864/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
TERPENE QUINONES |
en |
dc.subject |
CONICUM |
en |
dc.subject |
BENEFITS |
en |
dc.subject |
SPONGE |
en |
dc.subject |
RISKS |
en |
dc.title |
Anti-inflammatory Thiazine Alkaloids Isolated from the New Zealand Ascidian Aplidium sp.; Inhibitors of the Neutrophil Respiratory Burst in a Model of Gouty Arthritis. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1021/np060626o |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
936 |
en |
pubs.volume |
70 |
en |
dc.rights.holder |
Copyright: American Chemical Society |
en |
dc.identifier.pmid |
17497807 |
en |
pubs.end-page |
940 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
72129 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
17497807 |
en |