Abstract:
In 2000, Namikoshi et al. reported the isolation and structural elucidation of a novel [5,6]-bisbenzannulated spiroacetal [1] from the marine fungus Paecilomyces sp. [2] This unique spiro[chroman-2,1’(3’H)-isobenzofuran] derivative was identified as a potential antimitotic agent (20 % inhibition at 50 mm) using an assay screening for microtubule assembly inhibitors and was subsequently named paecilospirone (1).