The IUPS Physiome Project: progress and plans

Abstract

The IUPS Physiome Project aims to facilitate the understanding of physiological function in healthy and diseased mammalian tissues by developing a multi-scale modeling framework that can link biological structure and function across all spatial scales. To achieve this requires an open-source internationally collaborative effort to design XML standards for encapsulating models, web-accessible model databases, and computational tools for authoring and visualizing models and running model simulations. A brief overview of the project is given in this chapter, with a discussion of the current progress and future plans for three particular organ systems: the heart, lungs, and musculo-skeletal system.