dc.contributor.author |
Hopkins, Sarah |
en |
dc.contributor.author |
Baldi, JC |
en |
dc.contributor.author |
Cutfield, Wayne |
en |
dc.contributor.author |
McCowan, Lesley |
en |
dc.contributor.author |
Hofman, Paul |
en |
dc.date.accessioned |
2011-11-04T02:22:44Z |
en |
dc.date.issued |
2011 |
en |
dc.identifier.citation |
Clin Endocrinol (Oxf) 74:495-500 2011 |
en |
dc.identifier.issn |
0300-0664 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8678 |
en |
dc.description.abstract |
Context & Objective: A recent paper by our group reported that regular aerobic exercise during pregnancy led to lower fetal IGF-I and IGF-II concentrations and a modest reduction in offspring birth weight when compared with the offspring of non-training control participants. Maternal hormonal alterations in response to exercise training may be associated with the regulation of nutrient availability for fetal growth through placental regulation of maternal metabolism. Objective: To determine if the reduction in offspring size was associated with changes in the maternal IGF axis (including placental growth hormone [PGH]), leptin and/or FFA in response to aerobic exercise training in the second half of pregnancy. Design and Setting: A randomized, controlled trial of exercise in pregnancy. Patients: Eighty-four healthy nulliparous women (mean ± SD age 30 ± 4 yr, BMI 25.5 ± 4 kg/m(2) ). Measurements: Serum samples were drawn at 19 and 35 weeks gestation to determine serum IGF-I, IGF-II, IGF binding protein-1, IGF binding protein-3, PGH, leptin, and FFA. Results: Exercise training in pregnancy had no impact on the pregnancy-related changes in the maternal IGF axis. Women in the exercise group experienced a 29% increase in leptin in late gestation (P = 0.026 vs. control) and a trend towards lower FFA (P = 0.07 vs. control). Late pregnancy changes in maternal leptin were inversely related to offspring birth weight (r = -0.24, p < 0.05) and BMI (r = -0.25, p < 0.05). Conclusions: An increase in leptin in exercising pregnant women may reflect subtle changes within the placenta in response to regular exercise and may contribute to the reduction in offspring size previously reported in this cohort. |
en |
dc.language |
ENG |
en |
dc.publisher |
Blackwell Publishing Ltd |
en |
dc.relation.ispartofseries |
Clinical Endocrinology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0300-0664/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
GROWTH-FACTOR-I |
en |
dc.subject |
LEPTIN CONCENTRATIONS |
en |
dc.subject |
IGF-I |
en |
dc.subject |
LONGITUDINAL CHANGES |
en |
dc.subject |
INTRAUTERINE GROWTH |
en |
dc.subject |
BODY-COMPOSITION |
en |
dc.subject |
PLASMA LEPTIN |
en |
dc.subject |
PLACENTAL GH |
en |
dc.subject |
FETAL-GROWTH |
en |
dc.subject |
INSULIN |
en |
dc.title |
Effects of Exercise Training on Maternal Hormonal Changes in Pregnancy. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/j.1365-2265.2010.03964.x |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
495 |
en |
pubs.volume |
74 |
en |
dc.rights.holder |
Copyright: WILEY-BLACKWELL |
en |
dc.identifier.pmid |
21198740 |
en |
pubs.end-page |
500 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
202697 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Psychological Medicine Dept |
en |
pubs.record-created-at-source-date |
2011-03-15 |
en |
pubs.dimensions-id |
21198740 |
en |