The association between customised small for gestational age infants and pre-eclampsia or gestational hypertension varies with gestation at delivery

Show simple item record Allan, Katie en North, RA en Poppe, Katrina en Sadler, Lynn en McCowan, Lesley en 2011-11-07T20:02:20Z en 2007-04 en
dc.identifier.citation BJOG-An International Journal of Obstetrics and Gynaecology 114(4):478-484 2007 en
dc.identifier.issn 1470-0328 en
dc.identifier.uri en
dc.description.abstract Objectives:  (1) To describe the association between small for gestational age (SGA) infants and pre-eclampsia (PE) and gestational hypertension (GH) and (2) to determine how this association changes with gestational age at delivery using customised centiles to classify infants as SGA. Design:  A retrospective observational study. Setting:  National Women’s Hospital, a Tertiary Referral Centre in Auckland, New Zealand. Population:  A total of 17 855 nulliparous women delivering between 1992 and 1999. Methods:  A comparison of the number of women with a customised SGA infant, PE and GH according to gestational age at delivery. Main outcome measures:  The incidence of SGA infants (defined as birthweight <10th customised centile), PE and GH at <34, 34–36+6 and ≥37 weeks. Results:  A total of 1847 (10.3%) infants were SGA, 520 (2.9%) women had PE and 1361 (7.6%) had GH. SGA, PE and GH all occurred more commonly with increasing gestation at delivery with 85%, 62% and 90% of cases delivered at term. In women delivering SGA infants, coexisting PE was more likely to occur among those delivered preterm than at term (38.6% at <34 weeks [relative risk, RR 10.2 95%CI 7.3–14.4], 22.4% at 34–36+6 weeks [RR 6.0 95%CI 4.1–8.6] and 3.8% at ≥37 weeks [OR 1.0]). Women with preterm PE were more likely to have a SGA infant than women with term PE (57.1% at <34 weeks [RR 3.1 95%CI 2.3–4.2], 31.7% at 34–36+6 weeks [RR 1.7 95%CI 1.2–2.5]) and 18.3% at ≥37 weeks [OR 1.0]). There was a similar association between GH and SGA infants as gestation advanced (57.6% at <34 weeks [RR 4.8 95%CI 3.4–6.6], 30.5% at 34–36+6 weeks [RR 2.5 95%CI 1.8–3.5] and 12.1% ≥37 weeks [OR 1.0]). Conclusions:  SGA infants and PE are more likely to coexist in preterm births compared with term births. This is likely to reflect the degree of placental involvement in each disease process. en
dc.language EN en
dc.relation.ispartofseries BJOG: An International Journal of Obstetrics and Gynaecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject customised centiles en
dc.subject gestational hypertension en
dc.subject intrauterine growth restriction en
dc.subject pre-eclampsia en
dc.subject SGA en
dc.subject small for gestational age en
dc.subject FETAL-GROWTH en
dc.subject POPULATION en
dc.subject RISK en
dc.subject WOMEN en
dc.subject IMPACT en
dc.title The association between customised small for gestational age infants and pre-eclampsia or gestational hypertension varies with gestation at delivery en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1471-0528.2007.01277.x en
pubs.issue 4 en
pubs.begin-page 478 en
pubs.volume 114 en
dc.rights.holder Copyright: 2007 The Authors Journal compilation; RCOG 2007 BJOG An International Journal of Obstetrics and Gynaecology en
dc.identifier.pmid 17378821 en en
pubs.end-page 484 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 92345 en Liggins Institute en Medical and Health Sciences en Population Health en Epidemiology & Biostatistics en School of Medicine en Obstetrics and Gynaecology en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 17378821 en

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