Patterns of Change in Uterine Artery Doppler Studies Between 20 and 24 Weeks of Gestation and Pregnancy Outcomes

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dc.contributor.author Allan, Katie en
dc.contributor.author North, RA en
dc.contributor.author Stone, Peter en
dc.contributor.author Chan, EHY en
dc.contributor.author Taylor, Rennae en
dc.contributor.author Dekker, GA en
dc.contributor.author McCowan, Lesley en
dc.contributor.author SCOPE Consortium en
dc.date.accessioned 2011-11-07T20:08:59Z en
dc.date.issued 2009-02 en
dc.identifier.citation OBSTET GYNECOL 113(2):332-338 Feb 2009 en
dc.identifier.issn 0029-7844 en
dc.identifier.uri http://hdl.handle.net/2292/8757 en
dc.description.abstract OBJECTIVES: To describe changes in mean uterine artery resistance index and bilateral notches between 20 and 24 weeks of gestation in healthy nulliparous women and to relate these changes to pregnancy outcome.METHODS: A total of 2,189 nulliparous participants in the Screening for Pregnancy Endpoints study had pregnancy outcomes compared between four uterine artery Doppler groups: normal at 20 and 24 weeks of gestation (group 1), normal at 20 weeks and abnormal at 24 weeks (group 2), abnormal at 20 weeks and normal at 24 weeks (group 3), and abnormal at both 20 and 24 weeks (group 4). Abnormal uterine Doppler was defined as 1) mean resistance index greater than the 90th centile; 2) bilateral notches; and 3) a combination of 1, 2, or both. The main outcomes were preeclampsia and small for gestational age (SGA) neonates (less than the 10th customized centile).RESULTS: Preeclampsia developed in 116 (5.3%) women, and 223 (10.2%) delivered SGA neonates. With abnormal Doppler defined as mean resistance index greater than the 90th centile, the rate of SGA increased across Doppler group 1, 156 (8.4%); group 2, 13 (11%); group 3, 25 (19.5%); and group 4, 29 (35.4%) (P <.001). The rate of SGA was higher in group 3 compared with group 1. Preeclampsia differed among groups 1 (85 [4.6%]), 2 (9 [7.6%], 3 (7 [5.5%]), and 4 (15 [18.3%]) (P <.001).CONCLUSION: Pregnancy outcomes in women with abnormal uterine artery Doppler results at either 20 or 24 weeks were intermediate between those with normal or abnormal results at both time points. If overall test performance could be enhanced by the addition of clinical data, biomarkers, or both, we would recommend that 20 weeks is the most appropriate gestation in the second trimester to perform uterine artery Doppler studies. en
dc.language EN en
dc.publisher LIPPINCOTT WILLIAMS & WILKINS en
dc.relation.ispartofseries Obstetrics and Gynecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0029-7844/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject BIRTH-WEIGHT en
dc.subject WAVE-FORMS en
dc.subject PREECLAMPSIA en
dc.subject PREDICTION en
dc.subject POPULATION en
dc.subject HYPERTENSION en
dc.subject ULTRASOUND en
dc.subject RISK en
dc.title Patterns of Change in Uterine Artery Doppler Studies Between 20 and 24 Weeks of Gestation and Pregnancy Outcomes en
dc.type Journal Article en
dc.identifier.doi 10.1097/01.aoa.0000367035.56653.3f en
pubs.issue 2 en
pubs.begin-page 332 en
pubs.volume 113 en
dc.rights.holder Copyright: LIPPINCOTT WILLIAMS & WILKINS en
dc.identifier.pmid 19155903 en
pubs.end-page 338 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 92341 en
pubs.org-id Liggins Institute en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Obstetrics and Gynaecology en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19155903 en


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