dc.contributor.author |
Bhalla, A |
en |
dc.contributor.author |
Stone, Peter |
en |
dc.contributor.author |
Liddell, HS |
en |
dc.contributor.author |
Zanderigo, A |
en |
dc.contributor.author |
Chamley, Lawrence |
en |
dc.date.accessioned |
2011-11-07T20:43:47Z |
en |
dc.date.issued |
2006 |
en |
dc.identifier.citation |
Reproduction 131:583-589 2006 |
en |
dc.identifier.issn |
1470-1626 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8779 |
en |
dc.description.abstract |
Recurrent miscarriage affects 1% of all couples attempting pregnancy. Immunological factors are postulated to play a role in the aetiology of recurrent miscarriage because the fetus and placenta are immunologically different from the mother. In particular, altered expression of the, non-classical, class I histocompatibility leukocyte antigen (HLA) molecules has been postulated to play a role in the aetiology of recurrent miscarriage as the fetus and placenta are semi-allogenic to the mother. This study was conducted to examine whether altered expression of the non-classical class I HLA molecules, HLA-G and HLA-E, by cells at the maternofetal interface could play a role in the aetiology of recurrent miscarriage. First-trimester placental and decidual biopsies were obtained from 45 women with recurrent miscarriage and 17 gestation-matched normal controls. These biopsies were screened by immunohistochemistry for HLA-G and HLA-E and isotype-matched control antibodies. Staining was analysed by light microscopy and digital image analysis. In both recurrent miscarriage and normal pregnancy, HLA-G was localised to the extravillous trophoblast. There was no difference in the pattern of HLA-G expression between women with recurrent miscarriage and those with normal pregnancies. HLA-E was localised to the syncytiotrophoblast, villous mesenchymal cells, extravillous trophoblast and several decidual cell types, but staining for HLA-E appeared to be confined primarily to the cytoplasm. There was no difference in the pattern of HLA-E expression between women with recurrent miscarriage and those with normal pregnancies. |
en |
dc.language |
EN |
en |
dc.publisher |
Bio Scientifica Ltd |
en |
dc.relation.ispartofseries |
Reproduction |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1470-1626/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
SEQUENCE-DERIVED PEPTIDES |
en |
dc.subject |
PROTEIN EXPRESSION |
en |
dc.subject |
E BINDS |
en |
dc.subject |
CELLS |
en |
dc.subject |
TROPHOBLAST |
en |
dc.subject |
EPIDEMIOLOGY |
en |
dc.subject |
RECOGNITION |
en |
dc.subject |
CD94/NKG2A |
en |
dc.subject |
RECEPTORS |
en |
dc.subject |
PHENOTYPE |
en |
dc.title |
Comparison of the expression of human leucocyte antigen (HLA)-G and HLA-E in women with normal pregnancy and those with recurrent miscarriage |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1530/rep.1.00892 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
583 |
en |
pubs.volume |
131 |
en |
dc.rights.holder |
Copyright: 2006 Society for Reproduction and Fertility |
en |
dc.identifier.pmid |
16514201 |
en |
pubs.end-page |
589 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
47908 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
16514201 |
en |