dc.contributor.author |
MacDonald, AA |
en |
dc.contributor.author |
Herbison, GP |
en |
dc.contributor.author |
Showell, Marian |
en |
dc.contributor.author |
Farquhar, Cynthia |
en |
dc.date.accessioned |
2011-11-08T00:44:56Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Human Reproduction Update,16(3):293-311 2009 |
en |
dc.identifier.issn |
1355-4786 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/8810 |
en |
dc.description.abstract |
BACKGROUND It has been suggested that body mass index (BMI), especially obesity, is associated with subfertility in men. Semen parameters are central to male fertility and reproductive hormones also play a role in spermatogenesis. This review aimed to investigate the association of BMI with semen parameters and reproductive hormones in men of reproductive age. METHODS MEDLINE, EMBASE, Biological Abstracts, PsycINFO and CINAHL databases and references from relevant articles were searched in January and February 2009. Outcomes included for semen parameters were sperm concentration, total sperm count, semen volume, motility and morphology. Reproductive hormones included were testosterone, free testosterone, estradiol, FSH, LH, inhibin B and sex hormone binding globulin (SHBG). A meta-analysis was conducted to investigate sperm concentration and total sperm count. RESULTS In total, 31 studies were included. Five studies were suitable for pooling and the meta-analysis found no evidence for a relationship between BMI and sperm concentration or total sperm count. Overall review of all studies similarly revealed little evidence for a relationship with semen parameters and increased BMI. There was strong evidence of a negative relationship for testosterone, SHBG and free testosterone with increased BMI. CONCLUSIONS This systematic review with meta-analysis has not found evidence of an association between increased BMI and semen parameters. The main limitation of this review is that data from most studies could not be aggregated for meta-analysis. Population-based studies with larger sample sizes and longitudinal studies are required. |
en |
dc.language |
EN |
en |
dc.publisher |
Oxford University Press |
en |
dc.relation.ispartofseries |
Human Reproduction Update |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1355-4786/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
body mass index |
en |
dc.subject |
semen |
en |
dc.subject |
reproductive hormones |
en |
dc.subject |
systematic review |
en |
dc.subject |
obesity |
en |
dc.subject |
WAIST-HIP-RATIO |
en |
dc.subject |
OBESE MEN |
en |
dc.subject |
RISK-FACTORS |
en |
dc.subject |
HYPOGONADOTROPIC HYPOGONADISM |
en |
dc.subject |
TESTOSTERONE LEVELS |
en |
dc.subject |
ANDROGEN LEVELS |
en |
dc.subject |
INFERTILE MEN |
en |
dc.subject |
SEX-HORMONES |
en |
dc.subject |
QUALITY |
en |
dc.subject |
WEIGHT |
en |
dc.title |
The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1093/humupd/dmp047 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
293 |
en |
pubs.volume |
16 |
en |
dc.rights.holder |
Copyright: 2009 the author |
en |
dc.identifier.pmid |
19889752 |
en |
pubs.end-page |
311 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
91627 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
19889752 |
en |