dc.contributor.author |
Harris, Deborah |
en |
dc.contributor.author |
Weston, PJ |
en |
dc.contributor.author |
Williams, CE |
en |
dc.contributor.author |
Pleasants, AB |
en |
dc.contributor.author |
Battin, Malcolm |
en |
dc.contributor.author |
Spooner, CG |
en |
dc.contributor.author |
Harding, Jane |
en |
dc.date.accessioned |
2011-11-14T22:15:00Z |
en |
dc.date.issued |
2011 |
en |
dc.identifier.citation |
Journal of Pediatrics 159(5):755-760 2011 |
en |
dc.identifier.issn |
0022-3476 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/9071 |
en |
dc.description.abstract |
Objectives To determine whether there is a relationship between electroencephalography patterns and hypoglycemia, by using simultaneous cot-side amplitude integrated electroencephalography (aEEG) and continuous interstitial glucose monitoring, and whether non-glucose cerebral fuels modified these patterns. Study design Eligible babies were $32 weeks gestation, at risk for hypoglycemia, and admitted to the neonatal intensive care unit. Electrodes were placed in C3-P3, C4-P4 O1-O2 montages. A continuous interstitial glucose sensor was placed subcutaneously, and blood glucose was measured by using the glucose oxidase method. Non-glucose cerebral fuels were measured at study entry, exit, and during recognized hypoglycemia. Results A total of 101 babies were enrolled, with a median weight of 2179 g and gestation of 35 weeks. Twentyfour of the babies had aEEG recordings, and glucose concentrations were low (<2.6 mM). There were 103 episodes of low glucose concentrations lasting 5 to 475 minutes, but no observable changes in aEEG variables. Plasma concentrations of lactate, beta-hydroxybutyrate, and glycerol were low and did not alter during hypoglycemia. Conclusions Cot-side aEEG was not useful for the detection of neurological changes during mild hypoglycemia. Plasma concentrations of non-glucose cerebral fuels were low and unlikely to provide substantial neuroprotection. |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Journal of Pediatrics |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3476/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Cot-side electroencephalography monitoring is not clinically useful in the detection of mild neonatal hypoglycemia |
en |
dc.type |
Journal Article |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
755 |
en |
pubs.volume |
159 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
21658714 |
en |
pubs.author-url |
http://www.jpeds.com/search/quick |
en |
pubs.end-page |
760 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
239783 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
LiFePATH |
en |
dc.identifier.eissn |
1097-6833 |
en |
pubs.record-created-at-source-date |
2011-11-15 |
en |
pubs.dimensions-id |
21658714 |
en |